Chemistry and structural biology of androgen receptor.
作者信息
Gao Wenqing, Bohl Casey E, Dalton James T
机构信息
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
出版信息
Chem Rev. 2005 Sep;105(9):3352-70. doi: 10.1021/cr020456u.
Abstract
摘要
相似文献
1
Chemistry and structural biology of androgen receptor.雄激素受体的化学与结构生物学
Chem Rev. 2005 Sep;105(9):3352-70. doi: 10.1021/cr020456u.
2
Androgens and pharmacology.雄激素与药理学。
Andrologia. 2005 Dec;37(6):213-5. doi: 10.1111/j.1439-0272.2005.00691.x.
3
Regulation of androgen action.雄激素作用的调节。
Vitam Horm. 1999;55:309-52. doi: 10.1016/s0083-6729(08)60938-3.
4
Circumventing anti-androgen resistance by molecular design.通过分子设计规避抗雄激素耐药性。
J Am Chem Soc. 2007 Apr 4;129(13):3822-3. doi: 10.1021/ja0701154. Epub 2007 Mar 10.
5
The androgen receptor: an overview.雄激素受体：概述
Recent Prog Horm Res. 1994;49:249-74. doi: 10.1016/b978-0-12-571149-4.50017-9.
6
Androgens and prostate cancer: biology, pathology and hormonal therapy.雄激素与前列腺癌：生物学、病理学及激素治疗
Eur J Cancer. 1997 Apr;33(4):545-54. doi: 10.1016/s0959-8049(96)00444-3.
7
Molecular biology of the androgen responses.雄激素反应的分子生物学
Andrologia. 2005 Dec;37(6):209-10. doi: 10.1111/j.1439-0272.2005.00698.x.
8
Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.人雄激素受体配体结合结构域与EM5744（一种经合理设计的甾体配体，带有指向螺旋12的大基团链）复合物的结构表征
J Biol Chem. 2007 Oct 19;282(42):30910-9. doi: 10.1074/jbc.M705524200. Epub 2007 Aug 21.
9
Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer.雄激素受体轴的分子建模：雄激素受体干预雄激素非依赖性前列腺癌的合理依据。
BJU Int. 2005 Dec;96 Suppl 2:2-9. doi: 10.1111/j.1464-410X.2005.05940.x.
10
Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets.意想不到的大 B 环抗雄激素的结合取向及其对未来药物靶点的影响。
J Med Chem. 2011 Jun 9;54(11):3973-6. doi: 10.1021/jm2000097. Epub 2011 May 16.
引用本文的文献
1
Evodiamine Boosts AR Expression to Trigger Senescence and Halt Proliferation in OSCC Cells.吴茱萸碱增强AR表达以触发衰老并阻止OSCC细胞增殖。
Curr Issues Mol Biol. 2025 Jul 17;47(7):558. doi: 10.3390/cimb47070558.
2
High-Affinity Probes for Androgen Receptor Imaging: From Cells and Modeling to Whole-Body Fluorescent Applications.用于雄激素受体成像的高亲和力探针：从细胞与模型到全身荧光应用
J Med Chem. 2025 Aug 14;68(15):15812-15827. doi: 10.1021/acs.jmedchem.5c00836. Epub 2025 Jul 25.
3
Preclinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density.选择性雄激素受体调节剂RAD140增加肌肉质量和骨矿物质密度的临床前评估。
Physiol Rep. 2025 Jul;13(14):e70463. doi: 10.14814/phy2.70463.
4
A Computational and In Vitro Appraisal of Ostarine to Target Androgen Receptor in Glioma C6 Cells.奥司他丁对胶质瘤C6细胞中雄激素受体作用靶点的计算分析及体外评估
Cell Biochem Biophys. 2025 Jun 13. doi: 10.1007/s12013-025-01797-0.
5
Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers.转录因子与NIPBL/MAU2形成三元复合物，以使黏连蛋白定位于增强子处。
Nucleic Acids Res. 2025 May 10;53(9). doi: 10.1093/nar/gkaf415.
6
Characterization of lncRNA-protein interactions associated with Prostate cancer and Androgen receptors by molecular docking simulations.通过分子对接模拟对与前列腺癌和雄激素受体相关的长链非编码RNA-蛋白质相互作用进行表征。
Biochem Biophys Rep. 2025 Mar 9;42:101959. doi: 10.1016/j.bbrep.2025.101959. eCollection 2025 Jun.
7
Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers.转录因子与NIPBL/MAU2形成三元复合物，以使黏连蛋白定位于增强子处。
bioRxiv. 2025 Feb 19:2024.12.09.627537. doi: 10.1101/2024.12.09.627537.
8
Small-molecule disruption of androgen receptor-dependent chromatin clusters.小分子破坏雄激素受体依赖性染色质簇。
Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2406239121. doi: 10.1073/pnas.2406239121. Epub 2024 Nov 19.
9
Cross-Species Molecular Docking Method to Support Predictions of Species Susceptibility to Chemical Effects.支持预测物种对化学效应易感性的跨物种分子对接方法。
Comput Toxicol. 2024 May 27;30. doi: 10.1016/j.comtox.2024.100319.
10
Androgen Effects on Alcohol-induced Liver Fibrosis Are Controlled by a Notch-dependent Epigenetic Switch.雄激素对酒精性肝纤维化的影响受Notch依赖的表观遗传开关调控。
Cell Mol Gastroenterol Hepatol. 2025;19(1):101414. doi: 10.1016/j.jcmgh.2024.101414. Epub 2024 Sep 28.
本文引用的文献
1
Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.选择性雄激素受体调节剂治疗可改善去势大鼠的肌肉力量和身体成分，并预防骨质流失。
Endocrinology. 2005 Nov;146(11):4887-97. doi: 10.1210/en.2005-0572. Epub 2005 Aug 11.
2
Androgen receptor-cofactor interactions as targets for new drug discovery.雄激素受体-辅因子相互作用作为新药研发的靶点
Trends Pharmacol Sci. 2005 May;26(5):225-8. doi: 10.1016/j.tips.2005.03.002.
3
Structural basis for antagonism and resistance of bicalutamide in prostate cancer.比卡鲁胺在前列腺癌中拮抗作用和耐药性的结构基础
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6201-6. doi: 10.1073/pnas.0500381102. Epub 2005 Apr 15.
4
Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus.基于双环-1H-异吲哚-1,3(2H)-二酮核鉴定一类新型雄激素受体拮抗剂。
Bioorg Med Chem Lett. 2005 Jan 17;15(2):389-93. doi: 10.1016/j.bmcl.2004.10.051.
5
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.基于结构的双环-1H-异吲哚-1,3(2H)-二酮类雄激素受体拮抗剂的设计方法
Bioorg Med Chem Lett. 2005 Jan 17;15(2):271-6. doi: 10.1016/j.bmcl.2004.10.085.
6
The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.在米非司酮存在的情况下，雄激素受体通过其N端和C端招募核受体共抑制因子（N-CoR），揭示了雄激素受体拮抗剂的一种新分子机制。
J Biol Chem. 2005 Feb 25;280(8):6511-9. doi: 10.1074/jbc.M408972200. Epub 2004 Dec 14.
7
The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.[2.2.1] - 双环氮杂乙内酰脲作为雄激素受体拮抗剂的合成与评价
Bioorg Med Chem Lett. 2004 Dec 20;14(24):6107-11. doi: 10.1016/j.bmcl.2004.09.049.
8
Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance.雄激素受体结构域间及共激活因子相互作用的结构基础表明核受体激活功能优势发生了转变。
Mol Cell. 2004 Nov 5;16(3):425-38. doi: 10.1016/j.molcel.2004.09.036.
9
Principles for modulation of the nuclear receptor superfamily.核受体超家族的调控原则。
Nat Rev Drug Discov. 2004 Nov;3(11):950-64. doi: 10.1038/nrd1551.
10
Bicalutamide: clinical pharmacokinetics and metabolism.比卡鲁胺：临床药代动力学与代谢
Clin Pharmacokinet. 2004;43(13):855-78. doi: 10.2165/00003088-200443130-00003.
Zotero 插件