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苯基自由基通过加成到嘌呤碱基上并从糖部分夺取氢原子与二核苷磷酸发生反应。

Phenyl radicals react with dinucleoside phosphates by addition to purine bases and H-atom abstraction from a sugar moiety.

作者信息

Liu Ji-ang, Petzold Christopher J, Ramirez-Arizmendi Luis E, Perez James, Kenttämaa Hilkka

机构信息

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2038, USA.

出版信息

J Am Chem Soc. 2005 Sep 21;127(37):12758-9. doi: 10.1021/ja052766a.

DOI:10.1021/ja052766a
PMID:16159243
Abstract

Laser-induced acoustic desorption combined with mass spectrometry has been used to demonstrate that phenyl radicals can attack dinucleoside phosphates at both the sugar and base moieties, that purine bases are more susceptible to the attack than pyrimidine bases, and that the more electrophilic the radical, the more efficient the damage to dinucleoside phosphates.

摘要

激光诱导声解吸与质谱联用已被用于证明苯基自由基可在糖基和碱基部分攻击二核苷磷酸,嘌呤碱比嘧啶碱更容易受到攻击,并且自由基的亲电性越强,对二核苷磷酸的损伤就越有效。

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