Centerwall Corey R, Goodisman Jerry, Kerwood Deborah J, Dabrowiak James C
Department of Chemistry, Syracuse University, CST 1-014, Syracuse, New York 13244-4100, USA.
J Am Chem Soc. 2005 Sep 21;127(37):12768-9. doi: 10.1021/ja053353c.
The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.
描述了水合顺铂与存在于培养基和血液中的碳酸盐的反应。首先形成的络合物是一氯一碳酸根物种，在持续暴露于碳酸盐的情况下，它会缓慢形成双碳酸根络合物。在模拟治疗的条件下碳酸根物种的形成可能对顺铂的摄取、抗肿瘤特性和毒性具有重要意义。
