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[前列腺癌根治性放疗后的晚期效应]

[Late effects following curative radiotherapy for prostate cancer].

作者信息

Fokdal Lars U, Høyer Morten

机构信息

Arhus Universitetshospital, Arhus Sygehus, Onkologisk Afdeling, Arhus C.

出版信息

Ugeskr Laeger. 2005 Sep 12;167(37):3502-7.

Abstract

In this study we report late bladder, gastrointestinal and sexual dysfunctions in 23 patients following radical radiotherapy (66Gy-70Gy/33-35fx, 5 fx/week) for prostate cancer. We interviewed the subjects by telephone and compared the results with those of 45 healthy population controls. In general, the patients' bladder function was well preserved. However, compared with the population controls, significantly more patients reported dysuria and hematuria. Twenty-six percent of the patients reported moderate distress from the gastrointestinal tract. Fecal urgency, incontinence and the use of sanitary pads, as well as diarrhoea, and blood and mucous were significantly more common among the patients. Thirty-nine percent of the patients reported moderate or worse distress upon sexual activity, and significantly more patients suffered from erectile impotence.

摘要

在本研究中,我们报告了23例前列腺癌患者在接受根治性放疗(66Gy - 70Gy/33 - 35次分割,每周5次分割)后出现的晚期膀胱、胃肠道和性功能障碍。我们通过电话采访了这些受试者,并将结果与45名健康人群对照组进行了比较。总体而言,患者的膀胱功能保存良好。然而,与人群对照组相比,报告排尿困难和血尿的患者明显更多。26%的患者报告有中度胃肠道不适。在患者中,便急、失禁、使用卫生巾以及腹泻、便血和黏液便明显更为常见。39%的患者报告在性活动时有中度或更严重的不适,且患勃起功能障碍的患者明显更多。

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