Perosio P M, Brooks J J, Saul S H, Haller D G
Department of Pathology, University of Michigan Medical Center, Ann Arbor.
Am J Gastroenterol. 1992 Jul;87(7):894-8.
A 54-yr-old man with a 22-yr history of Crohn's disease was found to have a microscopic focus of immunoblastic lymphoma within a segment of small bowel resected to relieve intestinal obstruction. There was no other clinically evident disease. Thirty months later, he developed axillary adenopathy with recurrent lymphoma of the same immunophenotype (IgA lambda) and was given combination chemotherapy, with complete clinical response. Lymphoma recurred 6 months later in the axilla and progressed rapidly over the next 3 months, despite chemotherapy. He developed extensive mediastinal, mesenteric, and retroperitoneal disease with malignant ascites and died 39 months after diagnosis of the incidentally discovered bowel mucosal primary tumor.
一名患有22年克罗恩病病史的54岁男性，在为缓解肠梗阻而切除的一段小肠中发现了免疫母细胞淋巴瘤的微小病灶。无其他临床明显疾病。30个月后，他出现腋窝淋巴结病，复发了相同免疫表型（IgA λ）的淋巴瘤，并接受了联合化疗，临床完全缓解。6个月后淋巴瘤在腋窝复发，尽管进行了化疗，但在接下来的3个月中迅速进展。他出现了广泛的纵隔、肠系膜和腹膜后疾病以及恶性腹水，并在偶然发现肠黏膜原发性肿瘤诊断后39个月死亡。
