Clark Sunday, Long Aidan A, Gaeta Theodore J, Camargo Carlos A
Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
J Allergy Clin Immunol. 2005 Sep;116(3):643-9. doi: 10.1016/j.jaci.2005.06.026.
An earlier study of food-related anaphylaxis in the emergency department (ED) suggested low concordance with national guidelines for anaphylaxis management.
To extend these findings, we performed a chart review study to describe current ED management of insect sting allergy.
The Multicenter Airway Research Collaboration performed a chart review study in 15 North American EDs. Investigators reviewed 617 charts of patients with insect sting allergy. Patients were identified by using International Classification of Diseases, 9th Revision, codes 989.5 (toxic effect of venom), 995.0 (other anaphylactic shock), and 995.3 (allergy, unspecified).
The cohort was 42% female and 61% white, with a mean age of 36+/-19 years. In this cohort, 58% had local reactions, 11% had mild systemic reactions, and 31% had anaphylactic reactions, as defined by multisystem organ involvement or hypotension. Among patients with systemic reactions (mild or anaphylaxis), most (75%) were stung within 6 hours of ED arrival. While in the ED, 69% of systemic reaction patients received antihistamines, 50% systemic corticosteroids, and 12% epinephrine. Almost all systemic reaction patients (95%) were discharged to home. At ED discharge, 27% (95% CI, 22% to 33%) of systemic reaction patients received a prescription for self-injectable epinephrine. Only 20% (95% CI, 15% to 26%) had documentation of referral to an allergist.
Although guidelines suggest specific approaches for the emergency management of insect sting allergy, concordance with these guidelines appears low in patients with a severe insect sting reaction.
一项早期针对急诊科食物相关过敏反应的研究表明,其与国家过敏反应管理指南的一致性较低。
为扩展这些研究结果,我们开展了一项病历回顾研究,以描述急诊科目前对昆虫叮咬过敏的处理情况。
多中心气道研究协作组在北美15家急诊科开展了一项病历回顾研究。研究人员查阅了617例昆虫叮咬过敏患者的病历。通过使用国际疾病分类第九版编码989.5(毒液的毒性作用)、995.0(其他过敏性休克)和995.3(未特指的过敏)来识别患者。
该队列中42%为女性,61%为白人,平均年龄为36±19岁。在这个队列中,58%有局部反应,11%有轻度全身反应,31%有过敏反应,过敏反应定义为多系统器官受累或低血压。在有全身反应(轻度或过敏反应)的患者中,大多数(75%)在抵达急诊科后6小时内被叮咬。在急诊科时,69%的全身反应患者接受了抗组胺药治疗,50%接受了全身用糖皮质激素治疗,12%接受了肾上腺素治疗。几乎所有全身反应患者(95%)均出院回家。在急诊科出院时,27%(95%CI,22%至33%)的全身反应患者收到了自动注射肾上腺素的处方。只有20%(95%CI,15%至26%)有转诊至过敏症专科医生的记录。
尽管指南提出了昆虫叮咬过敏急诊处理的具体方法,但在有严重昆虫叮咬反应的患者中,与这些指南的一致性似乎较低。