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食物过敏急诊就诊情况的多中心研究。

Multicenter study of emergency department visits for food allergies.

作者信息

Clark Sunday, Bock S Allan, Gaeta Theodore J, Brenner Barry E, Cydulka Rita K, Camargo Carlos A

机构信息

Department of Emergency Medicine, Massachusetts General Hospital, Boston, Mass, USA.

出版信息

J Allergy Clin Immunol. 2004 Feb;113(2):347-52. doi: 10.1016/j.jaci.2003.10.053.

Abstract

BACKGROUND

Relatively little is known about the characteristics of patients who visit the emergency department (ED) for an acute allergic reaction. Although anaphylaxis guidelines suggest treatment with epinephrine, teaching about self-injectable epinephrine, and referral to an allergist, current ED management remains uncertain.

OBJECTIVE

The objective of this study was to describe the management of food-related acute allergic reactions.

METHODS

The Multicenter Airway Research Collaboration performed a chart review study in 21 North American EDs. Investigators reviewed a random sample of 678 charts of patients who presented with food allergy (International Classification of Diseases-ninth revision codes 693.1, 995.0, 995.3, and 995.60-995.69).

RESULTS

Patients had an average age of 29 years; the cohort was 57% female and 40% white. A variety of foods provoked the allergic reaction, including nuts (21%), crustaceans (19%), fruit (12%), and fish (10%). Although exposure to these foods can be life threatening, only 18% of patients came to the ED by ambulance. In the ED, 72% of patients received antihistamines, 48% received systemic corticosteroids, and 16% received epinephrine; 33% received respiratory treatments such as inhaled albuterol. Among patients with severe reactions (55% of total), 24% received epinephrine. Overall, 97% of patients were discharged to home. At ED discharge, 16% of patients were prescribed self-injectable epinephrine, and 12% were referred to an allergist.

CONCLUSIONS

Although guidelines suggest specific approaches for the management of acute allergic reactions, ED concordance for food allergy appears low. These findings support a new collaboration between professional organizations in allergy and emergency medicine and the development of educational programs and materials for ED patients and staff.

摘要

背景

对于因急性过敏反应前往急诊科(ED)就诊的患者特征,人们了解相对较少。尽管过敏反应指南建议使用肾上腺素治疗、教授自我注射肾上腺素以及转诊至过敏症专科医生,但目前急诊科的管理仍不明确。

目的

本研究的目的是描述与食物相关的急性过敏反应的管理情况。

方法

多中心气道研究协作组在北美21家急诊科进行了一项病历回顾研究。研究人员随机抽取了678例患有食物过敏(国际疾病分类第九版编码693.1、995.0、995.3以及995.60 - 995.69)患者的病历进行回顾。

结果

患者的平均年龄为29岁;该队列中女性占57%,白人占40%。多种食物引发了过敏反应,包括坚果(21%)、甲壳类动物(19%)、水果(12%)和鱼类(10%)。尽管接触这些食物可能危及生命,但只有18%的患者通过救护车前往急诊科。在急诊科,72%的患者接受了抗组胺药治疗,48%接受了全身性皮质类固醇治疗,16%接受了肾上腺素治疗;33%接受了诸如吸入沙丁胺醇等呼吸治疗。在有严重反应的患者(占总数的55%)中,24%接受了肾上腺素治疗。总体而言,97%的患者出院回家。在急诊科出院时,16%的患者被开了自我注射肾上腺素的处方,12%被转诊至过敏症专科医生。

结论

尽管指南提出了急性过敏反应管理的具体方法,但急诊科对食物过敏的依从性似乎较低。这些发现支持过敏和急诊医学专业组织之间开展新的合作,并为急诊科患者和工作人员开发教育项目及材料。

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