DiMarzo S J, Kennedy J F, Young P E, Hebert S A, Rosenberg D C, Villanueva B
Fertility Institute, Infertility Gynecology and Obstetrics Medical Group of San Diego, Inc., CA 92121.
Am J Obstet Gynecol. 1992 Jun;166(6 Pt 1):1607-12; discussion 1612-3. doi: 10.1016/0002-9378(92)91549-p.
Our objective was to evaluate the effect of controlled ovarian hyperstimulation on pregnancy rates after intrauterine insemination of washed husband's sperm.
In a private practice setting at the Infertility, Gynecology, and Obstetrics Medical Group in San Diego, 79 treatment programs included intrauterine insemination during natural cycles, 195 included clomiphene stimulation, and 53 had human menopausal gonadotropin stimulation. Pregnancy rates and monthly fecundabilities were calculated by life-table analysis and compared by the Z test.
By life-table analysis the cumulative probability of pregnancy after intrauterine insemination with no ovulation induction is 21.0% after six cycles with a monthly fecundability of 3.4%. With clomiphene the pregnancy rate is 32.7% with a monthly fecundability of 6.1%, and with human menopausal gonadotropin the pregnancy rate is 60.7% with a monthly fecundability of 13.0%. The human menopausal gonadotropin group had a significantly higher pregnancy rate and monthly fecundability as compared with the other two groups. There were no differences between the no-stimulation and the clomiphene groups.
Human menopausal gonadotropin stimulation results in a significantly higher pregnancy rate and monthly fecundability after intrauterine insemination as compared with no stimulation or clomiphene use.
我们的目的是评估控制性卵巢过度刺激对宫腔内人工授精洗涤丈夫精子后妊娠率的影响。
在圣地亚哥不孕不育、妇科和产科医疗集团的私人诊所环境中，79个治疗方案包括自然周期的宫腔内人工授精，195个包括克罗米芬刺激，53个采用人绝经期促性腺激素刺激。通过生命表分析计算妊娠率和每月受孕能力，并通过Z检验进行比较。
通过生命表分析，未进行排卵诱导的宫腔内人工授精六个周期后的累积妊娠概率为21.0%，每月受孕能力为3.4%。使用克罗米芬时，妊娠率为32.7%，每月受孕能力为6.1%，使用人绝经期促性腺激素时，妊娠率为60.7%，每月受孕能力为13.0%。与其他两组相比，人绝经期促性腺激素组的妊娠率和每月受孕能力显著更高。无刺激组和克罗米芬组之间没有差异。
与人绝经期促性腺激素未刺激或使用克罗米芬相比，人绝经期促性腺激素刺激在宫腔内人工授精后导致显著更高的妊娠率和每月受孕能力。
