Silverberg K M, Johnson J V, Olive D L, Burns W N, Schenken R S
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284-7836.
Fertil Steril. 1992 Feb;57(2):357-61. doi: 10.1016/s0015-0282(16)54845-6.
To compare a single periovulatory intrauterine insemination (IUI) with a regimen employing two IUIs, one before ovulation and one after ovulation, in patients undergoing controlled ovarian hyperstimulation with human menopausal gonadotropins (hMG) combined with human chorionic gonadotropin (hCG).
A randomized, prospective trial.
Thirty-one consecutive patients undergoing 49 cycles of controlled ovarian hyperstimulation/IUI were studied in a tertiary care setting.
Ovulation was determined sonographically. The establishment of a clinical pregnancy was defined by either ultrasonographic verification of cardiac activity within an intrauterine fetus, or histologic confirmation of trophoblast in a surgical specimen.
Clinical pregnancies developed in 2 of 23 cycles in the single insemination group, compared with 12 of the 23 cycles in the double insemination group. Cycle fecundity was significantly higher for group II (0.522) than for group I (0.087) patients (P = 0.003).
In hMG/hCG cycles, two IUIs timed as described above are superior to one periovulatory insemination.
在接受人绝经期促性腺激素（hMG）联合人绒毛膜促性腺激素（hCG）进行控制性卵巢刺激的患者中，比较单次排卵期宫内人工授精（IUI）与采用两次IUI的方案（一次在排卵前，一次在排卵后）。
一项随机、前瞻性试验。
在三级医疗中心对31例连续接受49个周期控制性卵巢刺激/IUI的患者进行研究。
通过超声检查确定排卵。临床妊娠的确定依据为超声检查证实宫内胎儿有心脏活动，或手术标本中滋养层的组织学确认。
单次授精组23个周期中有2例临床妊娠，而两次授精组23个周期中有12例临床妊娠。第二组（0.522）患者的周期受孕率显著高于第一组（0.087）患者（P = 0.003）。
在hMG/hCG周期中，按上述时间安排的两次IUI优于单次排卵期授精。
