Magnusson C M K, Roddam A W, Pike M C, Chilvers C, Crossley B, Hermon C, McPherson K, Peto J, Vessey M, Beral V
Cancer Research UK Epidemiology Unit, University of Oxford, Richard Doll Building, Headington, UK.
Br J Cancer. 2005 Oct 3;93(7):817-24. doi: 10.1038/sj.bjc.6602758.
We examined the relationship between body fatness, sports participation and breast cancer risk in 1560 premenopausal cases and 1548 controls, from three related population-based case-control studies in the UK. Half of the women with breast cancer were aged less than 36 years at diagnosis. Women who perceived themselves as plump at age 10 years had a relative risk of 0.83 (95% confidence interval 0.69-0.99, P = 0.03) as compared with those who perceived themselves as thin. Self-reported obesity compared with leanness at diagnosis was associated with a relative risk of 0.78 (95% confidence interval 0.56-1.06, P = 0.11). Women who reported having been plump at age 10 years and overweight or obese at diagnosis had a relative risk of 0.75 (95% confidence interval 0.56-1.01, P = 0.06) as compared with those who reported being thin at age 10 years and at diagnosis. Findings for three related measures of body fatness suggested that obesity is associated with a reduced risk of premenopausal breast cancer. There was no association between sports participation and breast cancer risk in these premenopausal women. The relative risk for spending an average of more than 1 h per week in sports compared with less from ages 12 to 30 years was 1.00 (95% CI 0.86-1.16, P = 0.98).
我们在来自英国三项相关的基于人群的病例对照研究中的1560例绝经前病例和1548例对照中，研究了体脂、体育活动参与情况与乳腺癌风险之间的关系。一半的乳腺癌女性在确诊时年龄小于36岁。10岁时自认为丰满的女性与自认为瘦的女性相比，相对风险为0.83（95%置信区间0.69 - 0.99，P = 0.03）。与诊断时瘦的女性相比，自我报告的肥胖与相对风险0.78相关（95%置信区间0.56 - 1.06，P = 0.11）。报告10岁时丰满且诊断时超重或肥胖的女性与报告10岁时及诊断时均瘦的女性相比，相对风险为0.75（95%置信区间0.56 - 1.01，P = 0.06）。三项相关体脂测量指标的结果表明，肥胖与绝经前乳腺癌风险降低相关。在这些绝经前女性中，体育活动参与情况与乳腺癌风险之间无关联。与12至30岁期间每周平均运动时间少于1小时的女性相比，每周平均运动时间超过1小时的女性的相对风险为1.00（95%置信区间0.86 - 1.16，P = 0.98）。
