Kosar Feridun, Acikgoz Nusret, Sahin Ibrahim, Topal Ergun, Aksoy Yuksel, Cehreli Sengul
Department of Cardiology, Faculty of Medicine, Inonu University, Turgut Ozal Medical Center, 44069 Malatya, Turkey.
Heart Vessels. 2005 Sep;20(5):199-202. doi: 10.1007/s00380-005-0831-y.
Coronary blood flow was quantified using the thrombosis in myocardial infarction (TIMI) frame-count method. This measurement has been significantly correlated with flow velocity measured invasively by use of a Doppler flow wire. Coronary artery ectasia or aneurysm (CEA) is thought to be present in patients with a slow blood flow. In this study, we aimed to assess the relationship between the ectasia size or ectasia ratio and TIMI frame count in patients with CEA. The study population included 58 patients with isolated CEA of the right coronary artery. In patients with CEA, an ectasia ratio was calculated as diameter of the ectatic segment/diameter of the adjacent normal segment. According to the ectasia ratio, ectatic vessels were divided into two groups: ectasias with a 1.5- to 2.0-fold increase (group A) and more than 2.0-fold increase (group B) in normal vessel diameter. Patients with a significant stenotic lesion (>50%) in the ectatic vessel were excluded. The control group was formed from a matched population of 35 patients with angiographically proven normal coronary arteries. Characteristics of the ectasia and control groups are similar. The TIMI frame counts for the right coronary artery (RCA) were significantly higher in the ectasia group as compared with the control group (43 +/- 12 vs 23 +/- 8, P < 0.001). The ectasia group had 38 patients in group A and 20 patients in group B. The TIMI frame counts were significantly higher in group B than in group A (43 +/- 10 vs 51 +/- 15, P < 0.05). The TIMI frame count of the RCA showed a significant correlation with the ectasia ratio and the maximum diameter of the ectatic segment (r = 0.578, P < 0.001 and r = 0.435, P < 0.001, respectively). Our data suggest that TIMI frame count measurement depends on the ectasia size or ectasia ratio, and an increased ectasia ratio is markedly associated with decreased TIMI frame counts in patients with CEA.
采用心肌梗死溶栓（TIMI）帧数法对冠状动脉血流进行定量分析。该测量结果与使用多普勒血流导线进行有创测量的血流速度显著相关。冠状动脉扩张或动脉瘤（CEA）被认为存在于血流缓慢的患者中。在本研究中，我们旨在评估CEA患者的扩张大小或扩张率与TIMI帧数之间的关系。研究人群包括58例孤立性右冠状动脉CEA患者。在CEA患者中，扩张率计算为扩张段直径/相邻正常段直径。根据扩张率，将扩张血管分为两组：正常血管直径增加1.5至2.0倍的扩张（A组）和增加超过2.0倍的扩张（B组）。扩张血管中存在显著狭窄病变（>50%）的患者被排除。对照组由35例经血管造影证实冠状动脉正常的匹配人群组成。扩张组和对照组的特征相似。与对照组相比，扩张组右冠状动脉（RCA）的TIMI帧数显著更高（43±12 vs 23±8，P<0.001）。扩张组中A组有38例患者，B组有20例患者。B组的TIMI帧数显著高于A组（43±10 vs 51±15，P<0.05）。RCA的TIMI帧数与扩张率和扩张段的最大直径显著相关（分别为r=0.578，P<0.001和r=0.435，P<0.001）。我们的数据表明，TIMI帧数测量取决于扩张大小或扩张率，在CEA患者中，扩张率增加与TIMI帧数减少显著相关。
