Pabot du Chatelard P, Merrer J
Service de Radiothérapie Oncologique, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris.
Ann Urol (Paris). 1992;26(2):112-8.
There are two other treatments for germ cell tumours of the testis apart from surgery: radiotherapy and chemotherapy. Radiotherapy is ideally administered with a linear accelerator delivering photons and electrons. The dose is well established and smaller volumes are now irradiated. The precision is increased by CT and by the use of personalized shields. Radiotherapy is indicated in pure seminomas, with two exceptions: rare seminomas with a large tumour mass (2%), rare palliative indications for non-seminomatous germ cell tumours. Chemotherapy, following the progress due to the combination of vinblastine and bleomycin, has been based, for the last 10 years, on cisplatin, which must be administered at the correct dose. VP 16, ifosfamide and other drugs have also been introduced. In forms with a poor prognosis and depending on the clinical course, this chemotherapy should be administered at high doses with the protection of autologous bone marrow transplantation. This requires an appropriate infrastructure and a well trained team. The short-term and long-term effects of radiotherapy are more clearly defined than effects of chemotherapy.
除手术外,睾丸生殖细胞肿瘤还有另外两种治疗方法:放疗和化疗。放疗理想情况下是使用能发射光子和电子的直线加速器进行。剂量已经确定,现在照射的体积更小。通过CT和使用个性化屏蔽装置提高了精确性。放疗适用于纯精原细胞瘤,但有两个例外:罕见的大肿瘤块精原细胞瘤(2%)、非精原细胞瘤性生殖细胞肿瘤罕见的姑息治疗指征。随着长春碱和博来霉素联合应用取得进展,在过去10年里,化疗一直以顺铂为基础,顺铂必须以正确剂量给药。还引入了依托泊苷、异环磷酰胺和其他药物。对于预后较差的类型,并根据临床病程,这种化疗应以高剂量进行,并采用自体骨髓移植保护。这需要适当的基础设施和训练有素的团队。放疗的短期和长期效果比化疗的效果更明确。