Baillard C, Adnet F, Borron S W, Racine S X, Ait Kaci F, Fournier J L, Larmignat P, Cupa M, Samama C M
Hôpital Avicenne, APHP, Département d'Anesthésie-Réanimation and SAMU 93-EA 3409, Bobigny Cedex, France.
Eur J Anaesthesiol. 2005 Sep;22(9):672-7. doi: 10.1017/s0265021505001110.
The ease of endotracheal intubation has been recently shown to affect the incidence of laryngeal injury. There remains controversy as to whether or not a muscle relaxant is routinely required for tracheal intubation. This study examined conditions of intubation in our routine practice, which employs a relaxant-sparing approach.
All adult patients scheduled for surgery with general anaesthesia were prospectively included. A muscle relaxant was used to facilitate intubation when it was required for the surgical procedure and/or otherwise regarded as necessary by the anaesthesiologist. In the remaining patients, a relaxant-free intubation was performed. Intubating conditions were evaluated in all the patients as well as the post-intubation laryngeal symptoms.
Between March and July 2003, 612 patients were consecutively included. A muscle relaxant was used in 32% of patients and no relaxant in the remaining patients (68%). Clinically acceptable intubating scores were observed in 98.4% overall with no significant difference between the two groups. Excellent conditions occurred more frequently in the relaxant group as compared to the relaxant-free group, 87% vs. 72%, P = 0.005. Laryngeal symptoms occurred in 184 (33%) patients with no difference between the two groups.
Our relaxant-sparing approach did not increase the incidence of poor conditions of intubation nor laryngeal symptoms. However, excellent conditions occurred more frequently in the relaxant group. A more flexible approach to the issue of the need for neuromuscular blockade prior to intubation is proposed.
近期研究表明气管插管的难易程度会影响喉损伤的发生率。对于气管插管是否常规需要使用肌肉松弛剂仍存在争议。本研究考察了我们采用减少肌肉松弛剂使用方法的常规操作中的插管情况。
前瞻性纳入所有计划接受全身麻醉手术的成年患者。当手术过程需要和/或麻醉医生认为必要时,使用肌肉松弛剂辅助插管。其余患者则进行无肌肉松弛剂插管。评估所有患者的插管条件以及插管后喉部症状。
2003年3月至7月期间,连续纳入612例患者。32%的患者使用了肌肉松弛剂,其余患者(68%)未使用。总体上98.4%的患者插管评分在临床可接受范围内,两组间无显著差异。与无肌肉松弛剂组相比,使用肌肉松弛剂组的极佳插管条件出现频率更高,分别为87%和72%,P = 0.005。184例(33%)患者出现喉部症状,两组间无差异。
我们减少肌肉松弛剂使用的方法并未增加插管条件不佳或喉部症状的发生率。然而,使用肌肉松弛剂组的极佳条件出现频率更高。对于插管前是否需要神经肌肉阻滞问题,提出了一种更灵活的方法。