Kaneko Hisatoshi, Kondo Takeshi, Fujiwara Toshiyuki, Iida Tomohiro, Miura Rika, Nakajima Haruhiko, Ishiko Hiroaki, Ariga Toshihide, Aoki Koki, Ohno Shigeaki, Suzutani Tatsuo
Department of Ophthalmology, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
Nippon Ganka Gakkai Zasshi. 2005 Aug;109(8):489-96.
To study the clinical features and virological analysis of the nosocomial adenoviral conjunctivitis cases occurring in the ophthalmology ward of Fukushima Medical University Hospital.
We studied the symptoms and clinical course of 61 patients who had adenoviral conjunctivitis caused by nosocomial infections in our hospital. We attempted to detect the adenovirus antigen, analyze the viral DNA, and isolate the virus from conjunctival swabs.
The clinical symptoms of adenoviral conjunctivitis were mainly conjunctival hyperemia, discharge and conjunctival follicles. Adenoviral conjunctivitis patients who had undergone ophthalmic surgery had conjunctivitis in the operated eye. The sensitivity of Adeno-check was 78.9% in the in-patients. Adenovirus type 37 variant was detected by molecular analysis and viral isolation.
Adenoviral conjunctivitis can often lead to outbreaks of nosocomial infection in the ophthalmic ward and sometimes requires makes necessary restriction of hospitalization and closing of the ward. Therefore, patients need to be observed carefully. The virological analysis of specimens from conjunctival swabs detected pathogens and provided useful information concerning adenoviral conjunctivitis.
研究福岛医科大学医院眼科病房发生的医院内腺病毒性结膜炎病例的临床特征及病毒学分析。
我们研究了我院61例因医院感染导致腺病毒性结膜炎患者的症状及临床病程。我们试图从结膜拭子中检测腺病毒抗原、分析病毒DNA并分离病毒。
腺病毒性结膜炎的临床症状主要为结膜充血、分泌物及结膜滤泡。接受眼科手术的腺病毒性结膜炎患者手术眼发生结膜炎。住院患者中腺病毒检测试剂盒（Adeno-check）的灵敏度为78.9%。通过分子分析和病毒分离检测到37型腺病毒变异株。
腺病毒性结膜炎常可导致眼科病房医院感染暴发，有时需要对住院进行必要限制并关闭病房。因此，需要对患者进行仔细观察。对结膜拭子标本进行病毒学分析可检测病原体，并为腺病毒性结膜炎提供有用信息。
