与成年雌性大鼠相比，青春期雌性大鼠对可卡因诱导的运动活动反应增强。
Heightened cocaine-induced locomotor activity in adolescent compared to adult female rats.
作者信息
Catlow Briony J, Kirstein Cheryl L
机构信息
Department of Psychology, Cognitive and Neural Sciences, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA.
出版信息
J Psychopharmacol. 2005 Sep;19(5):443-7. doi: 10.1177/0269881105056518.
Abstract
Initiation and experimentation with illicit drugs often occurs in adolescence. Evidence suggests that adolescent rats are more sensitive to some of the effects of drugs of abuse than adult rats. The present study investigated whether adolescent and adult female Sprague Dawley rats differ in cocaine-induced locomotor activity. Animals were placed in the test environment for 30 minutes, and then administered an intraperitoneal (IP) injection of either cocaine (20mg/kg) or saline (0.9%). Both adult and adolescent animals showed significant increases in locomotor activity as a result of cocaine administration compared to saline controls. Interestingly, cocaine induced significantly more locomotor activity in the adolescent females compared to the adults, demonstrating that cocaine acts differently in developing animals.
摘要
非法药物的初次使用和实验往往发生在青少年时期。有证据表明，青春期大鼠比成年大鼠对某些滥用药物的影响更敏感。本研究调查了青春期和成年雌性斯普拉格-道利大鼠在可卡因诱导的运动活动方面是否存在差异。将动物置于测试环境中30分钟，然后腹腔注射可卡因（20mg/kg）或生理盐水（0.9%）。与生理盐水对照组相比，成年和青春期动物在注射可卡因后运动活动均显著增加。有趣的是，与成年雌性相比，可卡因在青春期雌性中诱导的运动活动明显更多，这表明可卡因在发育中的动物体内作用不同。
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