Du Yi-an, Guo Jian-min, Zhang Yun-li, Zhou Li-xin, Zhang Ze-wei, Wang Xin-bao, Hu Jian-guo
Department of Hepatobiliary Pancreatic and Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2005 Jul;8(4):331-3.
To study the surgical treatment effect and factors influencing prognosis of recurrent carcinoma within gastric remnant.
From 1990 to 2003, clinical data of 60 patients underwent surgical operation again because of recurrence carcinoma within gastric remnant after radical resection were reviewed retrospectively.
The mean survival time was 32.6 months and the median survival time was 27.0 months. Thirty-seven patients (61.7%) received radical resection with the mean survival time of 45.0 months. Twenty-three patients received palliative treatment with the mean survival time of 12.7 months (P< 0.001). Univariate analysis showed that the clinical stages, pathologic classification, radical resection, peritoneal seeding, liver metastasis, the expression of CD44v6, PCNA and MVD were significantly correlated with survival time (P< 0.01), but were not correlated with sex,age,recurrence time after the first operation (P> 0.05). Multivariate analysis revealed that the clinical stages, peritoneal seeding and radical resection were independent prognostic factors.
The clinical stages, peritoneal seeding and radical resection are independent prognostic factors of recurrent carcinoma within gastric remnant. The radical resection maybe the most effective way to treat the recurrent carcinoma within gastric remnant.
探讨胃残端复发癌的手术治疗效果及影响预后的因素。
回顾性分析1990年至2003年因胃残端复发癌再次行手术治疗的60例患者的临床资料。
平均生存时间为32.6个月,中位生存时间为27.0个月。37例(61.7%)患者接受了根治性切除,平均生存时间为45.0个月。23例患者接受了姑息性治疗,平均生存时间为12.7个月(P<0.001)。单因素分析显示,临床分期、病理分级、根治性切除、腹膜种植、肝转移、CD44v6、PCNA及MVD表达与生存时间显著相关(P<0.01),但与性别、年龄、首次手术后复发时间无关(P>0.05)。多因素分析显示,临床分期、腹膜种植及根治性切除是独立的预后因素。
临床分期、腹膜种植及根治性切除是胃残端复发癌的独立预后因素。根治性切除可能是治疗胃残端复发癌的最有效方法。