Li Yawen, Ho Duc Hong Linh, Tyler Betty, Williams Tiffany, Tupper Malinda, Langer Robert, Brem Henry, Cima Michael J
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
J Control Release. 2005 Aug 18;106(1-2):138-45. doi: 10.1016/j.jconrel.2005.04.009.
A drug delivery micrcoelectromechanical systems (MEMS) device was used to locally deliver a chemotherapeutic agent (BCNU) to an experimental tumor in rats. This MEMS device consists of an array of reservoirs etched into the silicon substrate. The drug release is achieved by the electrochemical dissolution of the gold membranes covering the reservoirs. A new Pyrex package was developed to improve the BCNU release kinetics and enhance device capacity. Co-formulation of BCNU with polyethylene glycol (PEG) led to complete and rapid release of drug in vivo. BCNU delivered from the MEMS device showed dose-dependent inhibiting effect on the tumor growth in the BCNU dosage range of 0.67 approximately 2 mg. BCNU delivered from the activated devices was as effective as equipotent subcutaneous injections of BCNU in inhibiting tumor growth. Further optimization using this MEMS device to deliver BCNU in combination with other therapeutic agents against the tumor challenge is possible because of the unique capability of the device to precisely control the temporal release profiles of multiple substances.
一种药物递送微机电系统（MEMS）装置被用于向大鼠的实验性肿瘤局部递送化疗药物（卡莫司汀，BCNU）。该MEMS装置由蚀刻在硅基片上的储液器阵列组成。药物释放是通过覆盖储液器的金膜的电化学溶解来实现的。开发了一种新的派热克斯玻璃封装，以改善卡莫司汀的释放动力学并提高装置容量。卡莫司汀与聚乙二醇（PEG）的共同制剂导致药物在体内完全且快速释放。在0.67至约2毫克的卡莫司汀剂量范围内，从MEMS装置递送的卡莫司汀对肿瘤生长显示出剂量依赖性抑制作用。在抑制肿瘤生长方面，从激活装置递送的卡莫司汀与皮下注射等效剂量的卡莫司汀一样有效。由于该装置具有精确控制多种物质的时间释放曲线的独特能力，因此使用该MEMS装置进一步优化以递送卡莫司汀并与其他治疗剂联合应对肿瘤挑战是可行的。
