Institute of Medical &Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.
Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Nat Commun. 2017 Apr 13;8:15032. doi: 10.1038/ncomms15032.
Many implantable systems have been designed for long-term, pulsatile delivery of insulin, but the lifetime of these devices is limited by the need for battery replacement and consequent replacement surgery. Here we propose a batteryless, fully implantable insulin pump that can be actuated by a magnetic field. The pump is prepared by simple-assembly of magnets and constituent units and comprises a drug reservoir and actuator equipped with a plunger and barrel, each assembled with a magnet. The plunger moves to noninvasively infuse insulin only when a magnetic field is applied on the exterior surface of the body. Here we show that the dose is easily controlled by varying the number of magnet applications. Also, pump implantation in diabetic rats results in profiles of insulin concentration and decreased blood glucose levels similar to those observed in rats treated with conventional subcutaneous insulin injections.
许多植入式系统被设计用于长期、脉冲式地输送胰岛素，但这些设备的寿命受到电池更换的限制，需要进行更换手术。在这里，我们提出了一种无电池、完全可植入的胰岛素泵，可以通过磁场来驱动。该泵通过磁铁和组成单元的简单组装制备而成，包括一个药物储存器和一个带有柱塞和缸体的执行器，每个都装配有一个磁铁。只有在磁场施加于身体外表面时，柱塞才会移动，以无创方式输注胰岛素。在这里，我们表明通过改变施加磁场的次数，很容易控制剂量。此外，在糖尿病大鼠中进行的泵植入实验结果表明，胰岛素浓度和血糖水平的降低与接受传统皮下胰岛素注射治疗的大鼠相似。
