利用基因组学从共生细菌中提取天然产物。

Using genomics to deliver natural products from symbiotic bacteria.

作者信息

Clardy Jon

机构信息

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Genome Biol. 2005;6(9):232. doi: 10.1186/gb-2005-6-9-232. Epub 2005 Aug 31.

DOI:10.1186/gb-2005-6-9-232

PMID:16168093

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1242202/

Abstract

The availability of some natural products with promising anticancer activity has been limited because they are synthesized by symbiotic bacteria associated with specific animals. Recent research has identified the clusters of bacterial genes responsible for their synthesis, so that the molecules can be synthesized in alternative, easily cultured bacteria.

摘要

一些具有潜在抗癌活性的天然产物的可得性一直受到限制，因为它们是由与特定动物相关的共生细菌合成的。最近的研究已经确定了负责其合成的细菌基因簇，这样这些分子就可以在其他易于培养的细菌中合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/1242202/7c396d53f417/gb-2005-6-9-232-1.jpg

相似文献

Using genomics to deliver natural products from symbiotic bacteria.

Genome Biol. 2005;6(9):232. doi: 10.1186/gb-2005-6-9-232. Epub 2005 Aug 31.

Natural products genomics.

Microb Biotechnol. 2008 Jul;1(4):275-82. doi: 10.1111/j.1751-7915.2008.00044.x.

A reinvigorated era of bacterial secondary metabolite discovery.

Curr Opin Chem Biol. 2015 Feb;24:104-11. doi: 10.1016/j.cbpa.2014.10.014. Epub 2014 Dec 2.

Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology.

Chem Biol. 2013 May 23;20(5):636-47. doi: 10.1016/j.chembiol.2013.04.011.

Drug discovery from natural products.

J Ind Microbiol Biotechnol. 2006 Jul;33(7):523-31. doi: 10.1007/s10295-006-0107-2. Epub 2006 Mar 17.

[Advances on biosynthetic gene clusters of natural product from marine symbiotic microbe--a review].

Wei Sheng Wu Xue Bao. 2008 Jul;48(7):975-9.

Biochemical engineering of natural product biosynthesis pathways.

Metab Eng. 2001 Jan;3(1):4-14. doi: 10.1006/mben.2000.0172.

Bioactive natural products from novel microbial sources.

Ann N Y Acad Sci. 2015 Sep;1354:82-97. doi: 10.1111/nyas.12954.

Genomics-inspired discovery of natural products.

Curr Opin Chem Biol. 2011 Feb;15(1):22-31. doi: 10.1016/j.cbpa.2010.10.020. Epub 2010 Nov 25.

Bacterial endophytes: recent developments and applications.

FEMS Microbiol Lett. 2008 Jan;278(1):1-9. doi: 10.1111/j.1574-6968.2007.00918.x. Epub 2007 Nov 21.

引用本文的文献

Antibiotic resistance modifying ability of phytoextracts in anthrax biological agent Bacillus anthracis and emerging superbugs: a review of synergistic mechanisms.

Ann Clin Microbiol Antimicrob. 2021 Dec 2;20(1):79. doi: 10.1186/s12941-021-00485-0.

The evolution of antibiotic production rate in a spatial model of bacterial competition.

PLoS One. 2018 Oct 31;13(10):e0205202. doi: 10.1371/journal.pone.0205202. eCollection 2018.

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.

Nat Chem. 2011 Apr;3(4):331-5. doi: 10.1038/nchem.1002. Epub 2011 Feb 27.

Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.

Org Lett. 2010 Feb 19;12(4):716-9. doi: 10.1021/ol902751x.

Proliferation of antibiotic-producing bacteria and concomitant antibiotic production as the basis for the antibiotic activity of Jordan's red soils.

Appl Environ Microbiol. 2009 May;75(9):2735-41. doi: 10.1128/AEM.00104-09. Epub 2009 Mar 13.

Cytotoxicity of the ascidian Cystodytes dellechiajei against tumor cells and study of the involvement of associated microbiota in the production of cytotoxic compounds.

Mar Drugs. 2007 Jul 19;5(3):52-70. doi: 10.3390/md503052.

本文引用的文献

Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production.

Chembiochem. 2005 Oct;6(10):1760-5. doi: 10.1002/cbic.200500210.

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7315-20. doi: 10.1073/pnas.0501424102. Epub 2005 May 9.

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

J Nat Prod. 2005 Apr;68(4):493-6. doi: 10.1021/np0401664.

Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family.

J Nat Prod. 2005 Mar;68(3):472-9. doi: 10.1021/np049612d.

The evolving role of natural products in drug discovery.

Nat Rev Drug Discov. 2005 Mar;4(3):206-20. doi: 10.1038/nrd1657.

The role of natural product chemistry in drug discovery.

J Nat Prod. 2004 Dec;67(12):2141-53. doi: 10.1021/np040106y.

Lessons from natural molecules.

Nature. 2004 Dec 16;432(7019):829-37. doi: 10.1038/nature03194.

Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16222-7. doi: 10.1073/pnas.0405976101. Epub 2004 Nov 1.

Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes.

Angew Chem Int Ed Engl. 2003 Jun 30;42(25):2898-901. doi: 10.1002/anie.200351053.

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

Nat Biotechnol. 2003 Feb;21(2):187-90. doi: 10.1038/nbt784. Epub 2003 Jan 21.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

利用基因组学从共生细菌中提取天然产物。

Using genomics to deliver natural products from symbiotic bacteria.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

利用基因组学从共生细菌中提取天然产物。

Using genomics to deliver natural products from symbiotic bacteria.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献