Gullo Vincent P, McAlpine James, Lam Kin S, Baker Dwight, Petersen Frank
Cetek Corporation, 260 Cedar Hill Street, Marlborough, MA 01752, USA.
J Ind Microbiol Biotechnol. 2006 Jul;33(7):523-31. doi: 10.1007/s10295-006-0107-2. Epub 2006 Mar 17.
Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppressive disorders. Many of these compounds were discovered by applying recent advances in understanding the genetics of secondary metabolism in actinomycetes, exploring the marine environment and applying new screening technologies. In many instances, the discovery of a novel natural product serves as a tool to better understand targets and pathways in the disease process. This review describes recent progress in drug discovery from natural sources including several examples of compounds that inhibit novel drug targets.
天然产物化合物是众多治疗药物的来源。近期从天然产物来源发现药物的进展已产生了一些正在开发用于治疗癌症、耐药细菌和病毒以及免疫抑制性疾病的化合物。其中许多化合物是通过应用在放线菌次级代谢遗传学理解方面的最新进展、探索海洋环境以及应用新的筛选技术而发现的。在许多情况下，新型天然产物的发现可作为更好地理解疾病过程中的靶点和途径的工具。本综述描述了从天然来源发现药物的近期进展，包括一些抑制新型药物靶点的化合物实例。
