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High-dose-rate Brachytherapy as Adjuvant Local rEirradiation for Salvage Treatment of Recurrent breAst cancer (BALESTRA): a retrospective mono-institutional study.高剂量率近距离放射疗法作为复发性乳腺癌挽救性治疗的辅助局部再照射（BALESTRA）：一项回顾性单机构研究。
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Can the risk of secondary cancer induction after breast conserving therapy be reduced using intraoperative radiotherapy (IORT) with low-energy x-rays?保乳治疗后采用低能 X 射线术中放疗（IORT）能否降低继发癌症的风险？
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Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis.霍奇金淋巴瘤治疗后发生乳腺癌的临床结局：病例对照分析
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Intraoperative radiotherapy (IORT) is an option for patients with localized breast recurrences after previous external-beam radiotherapy.术中放疗（IORT）是既往接受过外照射放疗后出现局部乳腺复发患者的一种选择。
BMC Cancer. 2007 Sep 14;7:178. doi: 10.1186/1471-2407-7-178.

本文引用的文献

1
The MammoSite breast brachytherapy applicator: a review of technique and outcomes.MammoSite乳腺近距离放射治疗施源器：技术与结果综述
Brachytherapy. 2005;4(2):130-6. doi: 10.1016/j.brachy.2004.12.003.
2
Accelerated partial breast irradiation: a dosimetric comparison of three different techniques.加速部分乳腺照射：三种不同技术的剂量学比较
Brachytherapy. 2005;4(2):121-9. doi: 10.1016/j.brachy.2004.12.005.
3
Intraoperative radiotherapy: the debate continues.术中放疗：争论仍在继续。
Lancet Oncol. 2004 Jun;5(6):340. doi: 10.1016/S1470-2045(04)01489-5.
4
Intraoperative radiotherapy during breast conserving surgery in patients previously treated with radiotherapy for Hodgkin's disease.曾接受霍奇金病放疗的患者在保乳手术期间进行术中放疗。
Tumori. 2004 Jan-Feb;90(1):13-6. doi: 10.1177/030089160409000104.
5
Workshop on partial breast irradiation: state of the art and the science, Bethesda, MD, December 8-10, 2002.局部乳腺照射研讨会：最新技术与科学，马里兰州贝塞斯达，2002年12月8日至10日。
J Natl Cancer Inst. 2004 Feb 4;96(3):175-84. doi: 10.1093/jnci/djh023.
6
Surgical technique of intraoperative radiotherapy in conservative treatment of limited-stage breast cancer.局限性乳腺癌保守治疗中术中放疗的手术技术
Arch Surg. 2002 Jun;137(6):737-40. doi: 10.1001/archsurg.137.6.737.
7
A preliminary report of intraoperative radiotherapy (IORT) in limited-stage breast cancers that are conservatively treated.保乳治疗的局限性乳腺癌术中放疗（IORT）初步报告。
Eur J Cancer. 2001 Nov;37(17):2178-83. doi: 10.1016/s0959-8049(01)00285-4.
8
Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial.小乳腺癌保乳术后放疗：一项随机试验的长期结果
Ann Oncol. 2001 Jul;12(7):997-1003. doi: 10.1023/a:1011136326943.
9
The use of high-dose-rate brachytherapy alone after lumpectomy in patients with early-stage breast cancer treated with breast-conserving therapy.在接受保乳治疗的早期乳腺癌患者中，乳房切除术后单独使用高剂量率近距离放射治疗。
Int J Radiat Oncol Biol Phys. 2001 Jul 15;50(4):1003-11. doi: 10.1016/s0360-3016(01)01547-4.
10
Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer.在一组特定的I期乳腺癌患者中单独进行瘤床照射的保乳治疗。
Breast J. 2001 Mar-Apr;7(2):91-6. doi: 10.1046/j.1524-4741.2001.007002091.x.

曾因霍奇金病接受过放疗的早期乳腺癌患者的一种新选择：术中电子线放疗（ELIOT）。

A new option for early breast cancer patients previously irradiated for Hodgkin's disease: intraoperative radiotherapy with electrons (ELIOT).

作者信息

Intra Mattia, Gentilini Oreste, Veronesi Paolo, Ciocca Mario, Luini Alberto, Lazzari Roberta, Soteldo Javier, Farante Gabriel, Orecchia Roberto, Veronesi Umberto

机构信息

Department of Breast Surgery, European Institute of Oncology, Milan, Italy.

出版信息

Breast Cancer Res. 2005;7(5):R828-32. doi: 10.1186/bcr1310. Epub 2005 Aug 16.

DOI:10.1186/bcr1310
PMID:16168129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1242162/
Abstract

INTRODUCTION

Patients who have undergone mantle radiotherapy for Hodgkin's disease (HD) are at increased risk of developing breast cancer. In such patients, breast conserving surgery (BCS) followed by breast irradiation is generally considered contraindicated owing to the high cumulative radiation dose. Mastectomy is therefore recommended as the first option treatment in these women.

METHODS

Six patients affected by early breast cancer previously treated with mantle radiation for HD underwent BCS associated with full-dose intraoperative radiotherapy with electrons (ELIOT).

RESULTS

A total dose of 21 Gy (prescribed at 90% isodose) in five cases and 17 Gy (at 100% isodose) in one case were delivered directly to the mammary gland without acute complications and with good cosmetic results. After an average of 30.8 months of follow up, no late sequelae were observed and the patients are free of disease.

CONCLUSION

In patients previously irradiated for HD, ELIOT can avoid repeat irradiation of the whole breast, permit BCS and decrease the number of avoidable mastectomies.

摘要

引言

接受过霍奇金淋巴瘤（HD）斗篷野放疗的患者患乳腺癌的风险增加。在这类患者中，由于累积辐射剂量高，保乳手术（BCS）加乳腺照射通常被认为是禁忌的。因此，推荐乳房切除术作为这些女性的首选治疗方法。

方法

6例曾因HD接受斗篷野放疗的早期乳腺癌患者接受了BCS联合电子术中全剂量放疗（ELIOT）。

结果

5例患者乳腺直接接受了21 Gy的总剂量（规定在90%等剂量线上），1例患者接受了17 Gy（在100%等剂量线上），均无急性并发症，美容效果良好。平均随访30.8个月后，未观察到晚期后遗症，患者无疾病复发。

结论

对于曾接受过HD放疗的患者，ELIOT可避免对整个乳房进行重复照射，允许进行BCS，并减少不必要的乳房切除术数量。