乳腺发育的关键阶段：胚胎期乳腺形成所涉及的分子机制。
Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland.
作者信息
Hens Julie R, Wysolmerski John J
机构信息
Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, and Anlyan Center for Medical Research and Education, New Haven, Connecticut, USA.
出版信息
Breast Cancer Res. 2005;7(5):220-4. doi: 10.1186/bcr1306. Epub 2005 Aug 10.
The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wnt, fibroblast growth factor, and parathyroid hormone-related protein signaling. This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development.
胚胎乳腺的发育涉及表皮和间充质之间的相互作用，并由多种信号通路在时间和空间上进行协调。虽然可能有更多基因控制乳腺发育，但已确定Wnt、成纤维细胞生长因子和甲状旁腺激素相关蛋白信号传导的功能作用。这篇综述描述了关于调节胚胎乳腺发育的分子机制的已知情况。
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