小鼠乳腺中间充质依赖性形态发生和上皮特异性细胞分化
Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland.
作者信息
Sakakura T, Nishizuka Y, Dawe C J
出版信息
Science. 1976 Dec 24;194(4272):1439-41. doi: 10.1126/science.827022.
PMID:827022
Abstract
Isografts of heterotypic recombinants of embryonic mammary epithelium with salivary mesenchyme undergo development morphogenetically resembling that of salivary gland. However, cytodifferentiation of the epithelium is like that of mammary gland. In lactating hosts these isografts respond to endogenous hormonal stimulation and synthesize a milk protein, alpha-lactalbumin.
摘要
胚胎乳腺上皮与唾液腺间充质的异型重组体的同基因移植，在形态发生上经历类似于唾液腺的发育过程。然而，上皮细胞的细胞分化却类似于乳腺。在泌乳宿主中，这些同基因移植体对内源性激素刺激产生反应，并合成一种乳蛋白，即α-乳白蛋白。
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