p53的故事仍在继续——未来还有更多不眠之夜。
The continuing saga of p53--more sleepless nights ahead.
作者信息
Prives Carol, Manfredi James J
机构信息
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
出版信息
Mol Cell. 2005 Sep 16;19(6):719-21. doi: 10.1016/j.molcel.2005.08.024.
PMID:16168367
Abstract
Despite previous assumptions that the tumor suppressor protein p53 exists primarily and functionally as a single species, recent papers document the existence and unexpected properties of numerous p53 isoforms in cells. The complexity of p53 continues to unfold.
摘要
尽管之前认为肿瘤抑制蛋白p53主要以单一形式存在并发挥功能，但最近的论文证明了细胞中存在多种p53亚型及其意想不到的特性。p53的复杂性仍在不断展现。
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