Center for Comparative Oncology, University of California, Davis, California 95616, USA.
Histol Histopathol. 2010 Apr;25(4):515-26. doi: 10.14670/HH-25.515.
Cellular senescence is a permanent cell cycle arrest and a potent tumor suppression mechanism. The p53 tumor suppressor is a sequence-specific transcription factor and acts as a central hub sensing various stress signals and activating an array of target genes to induce cell cycle arrest, apoptosis, and senescence. Recent reports showed that restoration of p53 induces premature senescence and tumor regression in mice with hepatocarcinomas or sarcomas. Thus, p53-mediated senescence is capable of eliminating cancer cells in vivo. p63 and p73, two homologues of p53, have similar function in cell cycle arrest and apoptosis. However, the role of p63 and p73 in cellular senescence is elusive. In this review, we will discuss how p53 regulates senescence and future studies about p53 family members in senescence.
细胞衰老（Cellular senescence）是一种永久性的细胞周期停滞，也是一种强大的肿瘤抑制机制。p53 肿瘤抑制因子是一种序列特异性转录因子，作为一个中央枢纽，能够感知各种应激信号，并激活一系列靶基因，从而诱导细胞周期停滞、细胞凋亡和衰老。最近的报告显示，在患有肝癌或肉瘤的小鼠中，恢复 p53 可诱导过早衰老和肿瘤消退。因此，p53 介导的衰老能够在体内消除癌细胞。p63 和 p73 是 p53 的两个同源物，在细胞周期停滞和细胞凋亡方面具有相似的功能。然而，p63 和 p73 在细胞衰老中的作用尚不清楚。在这篇综述中，我们将讨论 p53 如何调节衰老，以及关于 p53 家族成员在衰老中的未来研究。
