Hardy Michele E
Veterinary Molecular Biology, P.O. Box 173610, Montana State University, Bozeman, MT 59717, USA.
FEMS Microbiol Lett. 2005 Dec 1;253(1):1-8. doi: 10.1016/j.femsle.2005.08.031. Epub 2005 Sep 6.
Noroviruses are positive strand RNA viruses that have received increased attention in recent years because their role as etiologic agents in acute gastroenteritis outbreaks is now clearly established. Much has been learned about the epidemiology of these viruses and the extent of genetic diversity among circulating strains. In contrast, progress on understanding the basic mechanisms of virus replication has been far slower due to the inability to cultivate virus in the laboratory. Despite this limitation, significant progress has been made in defining some basic functions of the norovirus proteins, and the structures of two have been solved to near atomic resolution. This minireview summarizes these recent advances in understanding the structure and function of the norovirus proteins and provides speculation about what roles they may play in the virus replication cycle.
诺如病毒是正链RNA病毒，近年来受到越来越多的关注，因为它们作为急性胃肠炎暴发的病原体的作用现已明确确立。关于这些病毒的流行病学以及流行毒株之间的遗传多样性程度，我们已经了解了很多。相比之下，由于无法在实验室中培养病毒，在理解病毒复制基本机制方面的进展要慢得多。尽管存在这一限制，但在确定诺如病毒蛋白的一些基本功能方面已经取得了重大进展，并且已经解析出其中两种蛋白的结构，分辨率接近原子水平。这篇微型综述总结了在理解诺如病毒蛋白结构和功能方面的这些最新进展，并对它们在病毒复制周期中可能发挥的作用进行了推测。
