Patterson Thomas F
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.
Lancet. 2005;366(9490):1013-25. doi: 10.1016/S0140-6736(05)67381-3.
Invasive mycoses pose a major diagnostic and therapeutic challenge. Advances in antifungal agents and diagnostic methods offer the potential for improved outcomes in patients with these infections, which are often lethal. Many fungal pathogens occur almost exclusively in opportunistic settings--in the immunocompromised host--and these infections are the focus of this review. Several areas of ongoing challenge remain, including the emergence of resistant organisms and the absence of reliable markers for early identification of patients at risk of developing invasive fungal disease. This Seminar reviews the changing epidemiology of invasive mycoses, new diagnostic methods, and recent therapeutic options and current management strategies for these opportunistic pathogens.
侵袭性真菌病带来了重大的诊断和治疗挑战。抗真菌药物和诊断方法的进展为改善这些往往致命的感染患者的治疗结果提供了可能。许多真菌病原体几乎仅在机会性环境中出现——即在免疫功能低下的宿主中——而这些感染是本综述的重点。仍存在几个持续面临挑战的领域，包括耐药菌的出现以及缺乏用于早期识别有发生侵袭性真菌病风险患者的可靠标志物。本研讨会综述了侵袭性真菌病不断变化的流行病学、新的诊断方法、近期的治疗选择以及针对这些机会性病原体的当前管理策略。
