Lalonde R, Kim H D, Maxwell J A, Fukuchi K
Université de Rouen, Faculté de Médecine et de Pharmacie, 22 bld Gambetta, INSERM U614, IFRMP 23, Bâtiment de Recherche, 76183 Rouen Cedex, France.
Neurosci Lett. 2005 Dec 23;390(2):87-92. doi: 10.1016/j.neulet.2005.08.028.
APP(695)SWE/co+PS1/DeltaE9 mice with Abeta plaques in neocortex and hippocampus were evaluated in tests of exploratory activity and spatial learning. On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.
在新皮层和海马体中存在β-淀粉样蛋白斑块的APP(695)SWE/co+PS1/DeltaE9小鼠，在探索活动和空间学习测试中接受了评估。在初始测试日，12个月大的APP(695)SWE/co+PS1/DeltaE9小鼠在高架十字迷宫的开放臂中比非转基因对照小鼠花费了更多时间。双转基因组在旷场中央区域的移动距离也更远，但在该区域停留的时间没有增加。只有双转基因组在T迷宫中的交替选择次数高于随机水平。在莫里斯水迷宫中，APP(695)SWE/co+PS1/DeltaE9小鼠在隐藏平台子任务和探针试验的习得过程中受损，但在可见平台测试中未受损。这些结果表明，在具有淀粉样病理的小鼠模型中存在选择性空间缺陷和去抑制倾向。
