Seufert Daniel W, Hegde Rashmi S, Nekkalapudi Srivamsi, Kelly Lisa E, El-Hodiri Heithem M
Center for Molecular and Human Genetics, Columbus Children's Research Institute, 700 Children's Dr., Columbus, OH 43026, USA.
Gene Expr Patterns. 2005 Dec;6(1):22-8. doi: 10.1016/j.modgep.2005.05.004. Epub 2005 Oct 5.
Members of the Ski/Sno family of gene products contain a characteristic peptide domain involved in protein-protein or protein-DNA interaction. Here, we characterize the developmental expression of xDawg, in Xenopus laevis, of a new gene, related to the Ski/Sno family of transcription regulators. The Ski/Sno domain of xDawg is predicted to present an electropositive surface, consistent with a role in DNA binding. This gene is expressed in the marginal zone of early gastrulae, and in the brain, sensory vesicles, and cranial neural crest of neurula and tailbud embryos.
Ski/Sno基因产物家族的成员包含一个参与蛋白质-蛋白质或蛋白质-DNA相互作用的特征性肽结构域。在此，我们描述了非洲爪蟾中一种与转录调节因子Ski/Sno家族相关的新基因xDawg的发育表达情况。预测xDawg的Ski/Sno结构域呈现正电表面，这与它在DNA结合中的作用相一致。该基因在早期原肠胚的边缘区、神经胚和尾芽胚胎的脑、感觉泡及颅神经嵴中表达。
