Laskowska Marzena, Laskowska Katarzyna, Leszczyńska-Gorzelak Bozena, Oleszczuk Jan
Department of Obstetrics and Perinatology, University School of Medicine in Lublin, Lublin, Poland.
Eur J Obstet Gynecol Reprod Biol. 2006 Jun 1;126(2):155-9. doi: 10.1016/j.ejogrb.2005.08.015. Epub 2005 Sep 19.
The aim of this study was to determine the maternal and umbilical vein soluble Fas and its ligand (sFasL) serum levels in pregnancies complicated by preeclampsia with intrauterine growth retardation (IUGR).
The study was carried out on 11 preeclamptic delivering patients in the third trimester of pregnancy with severe preeclampsia complicated by intrauterine growth retardation. The control group consisted of 12 healthy normotensive delivering patients with singleton uncomplicated pregnancies, without any renal, heart and vascular diseases and with normal laboratory tests. Maternal and umbilical serum soluble Fas and FasL concentrations were estimated using a sandwich ELISA assay.
Increased maternal and umbilical vein serum sFas and increased umbilical vein serum sFasL levels were found in the study group in comparison with the control group. In our study in both groups of patient higher maternal sFas values were observed in comparison with the umbilical cord blood. Further studies are necessary to evaluate the role of Fas/FasL pathway in pregnancies complicated by preeclampsia and intrauterine growth retardation.
本研究旨在测定合并子痫前期伴胎儿宫内生长受限（IUGR）的孕妇及脐静脉中可溶性Fas及其配体（sFasL）的血清水平。
本研究纳入11例妊娠晚期子痫前期患者，均为重度子痫前期合并胎儿宫内生长受限。对照组由12例健康的血压正常的单胎妊娠分娩患者组成，无任何肾脏、心脏和血管疾病，实验室检查正常。采用夹心酶联免疫吸附测定法评估孕妇和脐血中可溶性Fas和FasL的浓度。
与对照组相比，研究组孕妇及脐静脉血清sFas水平升高，脐静脉血清sFasL水平升高。在我们的研究中，两组患者的孕妇sFas值均高于脐带血。需要进一步研究以评估Fas/FasL途径在合并子痫前期和胎儿宫内生长受限的妊娠中的作用。
