Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
Neonatology. 2010;97(1):31-5. doi: 10.1159/000227290. Epub 2009 Jul 7.
The Fas-Fas ligand (FasL) pathway of apoptosis contributes to immune tolerance at the fetomaternal interface and has been ascribed a role in implantation and placental development. Intrauterine growth restriction (IUGR) may be associated with impaired maternal-fetal tolerance, resulting in increased trophoblast apoptosis and uteroplacental vascular insufficiency.
To investigate soluble Fas (sFas) and FasL (sFasL) concentrations in maternal, fetal and neonatal serum of IUGR and appropriate-for-gestational-age (AGA) pregnancies.
Circulating sFas and sFasL concentrations were determined in 40 mothers and their 20 IUGR (due to several etiologies) and 20 AGA singleton full-term fetuses and neonates on postnatal day 1 (N1) and 4 (N4).
No significant differences in sFas and sFasL concentrations were observed between groups. In both groups, maternal sFas concentrations were increased compared to fetal, N1 and N4 ones (p< or =0.005 in AGA and p < 0.001 in IUGR, in all cases). On the other hand, maternal sFasL concentrations were lower compared to fetal, N1 and N4 ones (p < 0.001 in all cases). Fetal sFasL concentrations were increased compared to maternal, but lower compared to N4 sFasL ones (p < 0.001 in AGA and p < or = 0.020 in IUGR, in all cases). N4 sFasL concentrations were elevated compared to N1 ones (p < 0.001).
Circulating maternal, as well as fetal sFas and sFasL concentrations do not differ between AGA controls and IUGR cases, irrespectively of the etiology of the latter. Furthermore, the results of this study imply an acceleration of Fas-FasL-mediated apoptosis during delivery and a respective decrease postpartum in both normal and IUGR pregnancies.
凋亡的 Fas-Fas 配体（FasL）途径有助于胎儿母体界面的免疫耐受，并被认为在植入和胎盘发育中起作用。宫内生长受限（IUGR）可能与母体-胎儿耐受受损有关，导致滋养细胞凋亡增加和胎盘血管功能不全。
研究 Fas 可溶性（sFas）和 FasL（sFasL）在 IUGR 和适合胎龄（AGA）妊娠的母、胎及新生儿血清中的浓度。
在产后第 1 天（N1）和第 4 天（N4），检测 40 名母亲及其 20 名 IUGR（由于多种病因）和 20 名 AGA 单胎足月胎儿和新生儿的循环 sFas 和 sFasL 浓度。
两组间 sFas 和 sFasL 浓度无显著差异。在两组中，与胎儿、N1 和 N4 相比，母体 sFas 浓度均升高（AGA 中均 p<0.005，IUGR 中均 p<0.001）。另一方面，与胎儿、N1 和 N4 相比，母体 sFasL 浓度均较低（所有病例均 p<0.001）。胎儿 sFasL 浓度高于母体，但低于 N4 sFasL 浓度（AGA 中均 p<0.001，IUGR 中均 p<0.020）。N4 sFasL 浓度高于 N1（p<0.001）。
AGA 对照组和 IUGR 病例组之间，循环母体、胎儿 sFas 和 sFasL 浓度无差异，与后者的病因无关。此外，本研究结果表明，在分娩过程中 Fas-FasL 介导的凋亡加速，产后相应减少，在正常和 IUGR 妊娠中均如此。
