Niewald Marcus, Wenzlawowicz Knut V, Fleckenstein Jochen, Wisser Lothar, Derouet Harry, Rübe Christian
Clinic for Radiooncology, The Saarland University Hospital, Homburg, Germany.
Int J Radiat Oncol Biol Phys. 2006 Jan 1;64(1):258-62. doi: 10.1016/j.ijrobp.2005.06.009. Epub 2005 Sep 19.
To retrospectively review the results of radiotherapy for Peyronie's disease.
In the time interval 1983-2000, 154 patients in our clinic were irradiated for Peyronie's disease. Of those, 101 had at least one complete follow-up data set and are the subject of this study. In the majority of patients, penis deviation was between 30 and 50 degrees , there were one or two indurated foci with a diameter between 5 and 15 mm. Pain was recorded in 48/92 patients. Seventy-two of the 101 patients received radiotherapy with a total dose of 30 Gy, and 25 received 36 Gy in daily fractions of 2.0 Gy. The remaining patients received the following dosage: 34 Gy (1 patient), 38-40 Gy (3 patients). Mean duration of follow-up was 5 years.
The best results ever at any time during follow-up were an improvement of deviation in 47%, reduction of number of foci in 32%, reduction of size of foci in 49%, and less induration in 52%. Approximately 50% reported pain relief after radiotherapy. There were 28 patients with mild acute dermatitis and only 4 patients with mild urethritis. There were no long-term side effects.
Our results compare well with those of other studies in the literature. In our patient cohort, radiotherapy was an effective therapy option with only very rare and mild side effects.
回顾性分析佩罗尼氏病的放射治疗结果。
在1983年至2000年期间，我院154例佩罗尼氏病患者接受了放射治疗。其中101例患者至少有一组完整的随访数据集，是本研究的对象。大多数患者阴茎弯曲角度在30至50度之间，有一两个硬结病灶，直径在5至15毫米之间。92例患者中有48例记录有疼痛。101例患者中72例接受了总剂量30Gy的放射治疗，25例接受了36Gy的放射治疗，每日分次剂量为2.0Gy。其余患者接受了以下剂量：34Gy（1例），38 - 40Gy（3例）。平均随访时间为5年。
随访期间任何时候的最佳结果是，阴茎弯曲改善率为47%，病灶数量减少率为32%，病灶大小缩小率为49%，硬结减轻率为52%。约50%的患者报告放射治疗后疼痛缓解。有28例患者出现轻度急性皮炎，仅4例患者出现轻度尿道炎。无长期副作用。
我们的结果与文献中其他研究的结果相当。在我们的患者队列中，放射治疗是一种有效的治疗选择，副作用非常罕见且轻微。
