Poulakis Vassilis, Skriapas Konstantinos, de Vries Rachelle, Dillenburg Wolfgang, Ferakis Nikolaos, Witzsch Ulrich, Melekos Michael, Becht Edward
Department of Urology, Nordwest Krankenhaus, Steinbacher Hohl 2-26, Frankfurt am Main D-60488, Germany.
Asian J Androl. 2006 May;8(3):361-6. doi: 10.1111/j.1745-7262.2006.00138.x.
To determine retrospectively the safety and efficacy of extracorporeal shock wave therapy (ESWT) in patients with Peyronie's disease.
Fifty-three patients with stable Peyronie's disease underwent ESWT (group 1). Fifteen patients matched with the baseline characteristic of the patients in group 1, who received no treatment, were used as the control (group 2). The patients' erectile function (International Index of Erectile Function [IIEF-5] score), pain severity (visual analog scale), plaque size and degree of penile angulation were assessed before and after the treatment in group 1 and during the follow-up in group 2.
The mean follow-up time was 32 months (range: 6-64 months) in group 1 and 35 months (range: 9-48 months) in group 2. All the patients were available for the follow-up. Considering erectile function and plaque size, no significant changes (P > 0.05) were observed in group 1 before or after the ESWT. A total of 39 patients (74%) reported a significant effect in pain relief in group 1 after ESWT. However, regarding improvement in pain, IIEF-5 score and plaque size, no significant differences were observed between the two groups. In 21 patients (40%) of group 1, the deviation angle was decreased more than 10 degrees with a mean reduction in all patients of 11 degrees (range: 6-20 degrees). No serious complications were noted considering ESWT procedure.
ESWT is a minimally invasive and safe alternative procedure for the treatment of Peyronie's disease. However, the effect of ESWT on penile pain, sexual function and plaque size remains questionable.
回顾性确定体外冲击波疗法（ESWT）治疗佩罗尼氏病患者的安全性和有效性。
53例病情稳定的佩罗尼氏病患者接受ESWT治疗（第1组）。15例与第1组患者基线特征匹配但未接受治疗的患者作为对照（第2组）。在第1组治疗前后以及第2组随访期间，评估患者的勃起功能（国际勃起功能指数[IIEF-5]评分）、疼痛严重程度（视觉模拟量表）、斑块大小和阴茎弯曲度。
第1组平均随访时间为32个月（范围：6 - 64个月），第2组为35个月（范围：9 - 48个月）。所有患者均完成随访。就勃起功能和斑块大小而言，第1组ESWT治疗前后未观察到显著变化（P > 0.05）。第1组共有39例患者（74%）报告ESWT治疗后疼痛缓解效果显著。然而，在疼痛改善、IIEF-5评分和斑块大小方面，两组之间未观察到显著差异。第1组21例患者（40%）的弯曲角度减小超过10度，所有患者平均减小11度（范围：6 - 20度）。未发现与ESWT治疗相关的严重并发症。
ESWT是治疗佩罗尼氏病的一种微创且安全的替代方法。然而，ESWT对阴茎疼痛、性功能和斑块大小的疗效仍存在疑问。
