Koo Hye-Jin, Lim Kyung-Hwa, Jung Hyun-Joo, Park Eun-Hee
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
J Ethnopharmacol. 2006 Feb 20;103(3):496-500. doi: 10.1016/j.jep.2005.08.011. Epub 2005 Sep 19.
Gardenia fruit has been traditionally used as a folk medicine for centuries in Asian countries. Extraction with ethanol was used to obtain an extract (GFE) that contains two known constituents, geniposide and genipin, which were subsequently evaluated for anti-inflammatory activity. GFE, genipin, and geniposide showed acute anti-inflammatory activities in carrageenan-induced rat paw edema. In a dose-dependent manner, GFE also inhibited vascular permeability induced by acetic acid. Both genipin and geniposide inhibited production of exudate and nitric oxide (NO) in the rat air pouch edema model. However, genipin possessed stronger anti-inflammatory activity than geniposide, as demonstrated by the results with carrageenan-induced rat paw edema, carrageenan-induced air pouch formation, and measurement of NO content in the exudates. GFE caused a dose-dependent inhibition of acetic acid-induced abdominal writhing in mice. Collectively, genipin, rather than geniposide, is the major anti-inflammatory component of gardenia fruit.
几个世纪以来，栀子果实一直在亚洲国家被传统用作民间药物。采用乙醇提取法获得了一种提取物（GFE），其含有两种已知成分京尼平苷和京尼平，随后对其抗炎活性进行了评估。GFE、京尼平和京尼平苷在角叉菜胶诱导的大鼠足爪肿胀中表现出急性抗炎活性。GFE还以剂量依赖的方式抑制了乙酸诱导的血管通透性。在大鼠气囊水肿模型中，京尼平和京尼平苷均抑制了渗出物和一氧化氮（NO）的产生。然而，在角叉菜胶诱导的大鼠足爪肿胀、角叉菜胶诱导的气囊形成以及渗出物中NO含量的测定结果表明，京尼平的抗炎活性比京尼平苷更强。GFE对乙酸诱导的小鼠腹部扭体反应产生剂量依赖性抑制作用。总体而言，栀子果实的主要抗炎成分是京尼平，而非京尼平苷。
