Li Dipeng, Liang Renjie, Wang Yirong, Zhou Yanting, Cai Weibang
Hangzhou Ninth People's Hospital Hangzhou China.
Department of Sports Medicine Zhejiang University School of Medicine Hangzhou China.
Health Sci Rep. 2024 Aug 12;7(8):e2295. doi: 10.1002/hsr2.2295. eCollection 2024 Aug.
To compare different methods of preparing silk fibroin hydrogels, then summarize the applications of silk fibroin hydrogel-based scaffolds in skin regeneration and finally discuss about future prospects to inspire people interested in this field.
A narrative review of the relevant papers was conducted. Notably, for applications in skin regeneration, this review provides a categorized summary and discussion of studies from the past decade.
Silk fibroin is a naturally occurring, biocompatible biomaterial that is easily producible. Thanks to its exceptional processability, silk fibroin has found diverse applications in skin regeneration. These applications encompass sponges, fiber fabrics, thin films, and hydrogels. Hydrogels, in particular, are noteworthy due to their water-containing network structure, closely resembling natural tissues. They provide a biomimetic three-dimensional growth environment for cells and have the capacity to incorporate growth factors. Consequently, there are abundant studies of silk fibroin hydrogel-based scaffolds in skin regeneration. Besides, some commercialized medical devices are also made of silk fibroin.
Silk fibroin hydrogel could be prepared with multiple methods and it is widely used in constructing scaffolds for efficient skin regeneration. In the future, silk fibroin hydrogel-based skin scaffolds could be more biomimetic and smart.
比较制备丝素蛋白水凝胶的不同方法，总结基于丝素蛋白水凝胶的支架在皮肤再生中的应用，并最终探讨未来前景，以启发该领域的相关人士。
对相关论文进行叙述性综述。值得注意的是，对于在皮肤再生中的应用，本综述对过去十年的研究进行了分类总结和讨论。
丝素蛋白是一种天然存在的、具有生物相容性且易于生产的生物材料。由于其卓越的加工性能，丝素蛋白在皮肤再生中有着广泛的应用。这些应用包括海绵、纤维织物、薄膜和水凝胶。特别是水凝胶，因其含水网络结构与天然组织极为相似而值得关注。它们为细胞提供了仿生三维生长环境，并具有容纳生长因子的能力。因此，有大量关于基于丝素蛋白水凝胶的支架在皮肤再生中的研究。此外，一些商业化的医疗设备也是由丝素蛋白制成的。
丝素蛋白水凝胶可以通过多种方法制备，并且广泛应用于构建高效皮肤再生的支架。未来，基于丝素蛋白水凝胶的皮肤支架可能会更具仿生学和智能化。
