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本文引用的文献

1
Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends.不同的机制控制果蝇CLIP-190定位于未附着的动粒和微管正端。
J Cell Sci. 2005 Aug 15;118(Pt 16):3781-90. doi: 10.1242/jcs.02504.
2
Drosophila Cks30A interacts with Cdk1 to target Cyclin A for destruction in the female germline.果蝇Cks30A与Cdk1相互作用，以靶向细胞周期蛋白A使其在雌性生殖系中被降解。
Development. 2005 Aug;132(16):3669-78. doi: 10.1242/dev.01940. Epub 2005 Jul 20.
3
Mini spindles, the XMAP215 homologue, suppresses pausing of interphase microtubules in Drosophila.微小纺锤体，即XMAP215的同源物，可抑制果蝇间期微管的暂停。
EMBO J. 2005 Apr 6;24(7):1387-96. doi: 10.1038/sj.emboj.7600629. Epub 2005 Mar 17.
4
Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.Cks2对哺乳动物减数分裂第一次中期/后期转换的需求。
Science. 2003 Apr 25;300(5619):647-50. doi: 10.1126/science.1084149.
5
The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle.纺锤体相关跨膜蛋白Axs识别出一种包裹减数分裂纺锤体的膜状结构。
Nat Cell Biol. 2003 Mar;5(3):261-3. doi: 10.1038/ncb944.
6
subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster.subito基因编码一种在黑腹果蝇减数分裂纺锤体极形成过程中所需的类驱动蛋白。
Genetics. 2002 Apr;160(4):1489-501. doi: 10.1093/genetics/160.4.1489.
7
Dis1/TOG universal microtubule adaptors - one MAP for all?Dis1/TOG通用微管适配体——一种适用于所有情况的微管相关蛋白？
J Cell Sci. 2001 Nov;114(Pt 21):3805-12. doi: 10.1242/jcs.114.21.3805.
8
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.哺乳动物Cks1的一种不依赖细胞周期蛋白依赖性激酶（CDK）的功能：将SCF（Skp2）靶向细胞周期蛋白依赖性激酶抑制剂p27Kip1 。
Mol Cell. 2001 Mar;7(3):639-50. doi: 10.1016/s1097-2765(01)00210-6.
9
Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles.Msps蛋白定位于无中心体极，以确保果蝇减数分裂纺锤体的双极性。
Nat Cell Biol. 2001 Jul;3(7):637-42. doi: 10.1038/35083025.
10
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.细胞周期调节蛋白Cks1是SCF（Skp2）介导的p27泛素化所必需的。
Nat Cell Biol. 2001 Mar;3(3):321-4. doi: 10.1038/35060126.

Cks/Suc1在果蝇雌性减数分裂无中心体纺锤体形成中的前后期作用。

A pre-anaphase role for a Cks/Suc1 in acentrosomal spindle formation of Drosophila female meiosis.

作者信息

Pearson Neil J, Cullen C Fiona, Dzhindzhev Nikola S, Ohkura Hiroyuki

机构信息

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, UK.

出版信息

EMBO Rep. 2005 Nov;6(11):1058-63. doi: 10.1038/sj.embor.7400529. Epub 2005 Sep 9.

DOI:10.1038/sj.embor.7400529
PMID:16170306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1371029/
Abstract

Conventional centrosomes are absent from a female meiotic spindle in many animals. Instead, chromosomes drive spindle assembly, but the molecular mechanism of this acentrosomal spindle formation is not well understood. We have screened female sterile mutations for defects in acentrosomal spindle formation in Drosophila female meiosis. One of them, remnants (rem), disrupted bipolar spindle morphology and chromosome alignment in non-activated oocytes. We found that rem encodes a conserved subunit of Cdc2 (Cks30A). As Drosophila oocytes arrest in metaphase I, the defect represents a new Cks function before metaphase-anaphase transition. In addition, we found that the essential pole components, Msps and D-TACC, were often mislocalized to the equator, which may explain part of the spindle defect. We showed that the second cks gene cks85A, in contrast, has an important role in mitosis. In conclusion, this study describes a new pre-anaphase role for a Cks in acentrosomal meiotic spindle formation.

摘要

在许多动物中，雌性减数分裂纺锤体没有传统的中心体。相反，染色体驱动纺锤体组装，但是这种无中心体纺锤体形成的分子机制尚未得到很好的理解。我们已经筛选了雌性不育突变体，以寻找果蝇雌性减数分裂中无中心体纺锤体形成的缺陷。其中一个突变体，remnants（rem），破坏了未激活卵母细胞中的双极纺锤体形态和染色体排列。我们发现rem编码Cdc2（Cks30A）的一个保守亚基。由于果蝇卵母细胞停滞在减数第一次分裂中期，该缺陷代表了中期-后期转换之前一种新的Cks功能。此外，我们发现关键的纺锤极组分Msps和D-TACC经常错误定位于赤道，这可能解释了部分纺锤体缺陷。相比之下，我们发现第二个cks基因cks85A在有丝分裂中具有重要作用。总之，本研究描述了Cks在无中心体减数分裂纺锤体形成中前期的一个新作用。