Prox1单倍剂量不足导致的淋巴管缺陷会引发成人期肥胖。
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
作者信息
Harvey Natasha L, Srinivasan R Sathish, Dillard Miriam E, Johnson Nicole C, Witte Marlys H, Boyd Kelli, Sleeman Mark W, Oliver Guillermo
机构信息
Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
出版信息
Nat Genet. 2005 Oct;37(10):1072-81. doi: 10.1038/ng1642. Epub 2005 Sep 18.
Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
多个器官协同调节食欲、新陈代谢以及葡萄糖和脂肪酸的稳态。在此，我们鉴定并表征了淋巴管功能障碍是成人期肥胖的一个原因。我们发现，同源盒基因Prox1的单个等位基因功能失活会导致成人期肥胖，这是由于淋巴管形态异常和破裂导致淋巴异常渗漏所致。Prox1杂合小鼠是成人期肥胖和淋巴管疾病的一种新模型。
Zotero 插件