Glinton Kristofor, Thakkar Abhishek V, Jones Rebecca, Inui Hiroyasu, Ge Zhi-Dong, Thorp Edward B
Feinberg School of Medicine, Department of Pathology, Northwestern University, Chicago, IL 60611, United States of America.
The Heart Center and Cardiovascular-Thoracic Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill, United States of America.
J Mol Cell Cardiol. 2025 Jan;198:13-20. doi: 10.1016/j.yjmcc.2024.11.006. Epub 2024 Nov 26.
Advances in genetic, pharmacologic, and sequencing technology have led to new insight into the role of lymphatics in health and disease. This includes fundamental aspects of the crosstalk between immune cells with cardiac lymphatics. At the interface between leukocytes and lymphatic endothelial cells, myeloid populations are sources of lymphatic growth factors during inflammation. Lymphatic endothelial cells also secrete signals that activate leukocytes, including to antigen presenting cells. Taken together, a view of the lymphatic vasculature as a supplemental cardiac immune hub is emerging. Herein, we discuss reciprocal cell and molecular crosstalk between leukocytes and lymphatics in the myocardium, with implications for health and cardiac inflammation.
遗传学、药理学和测序技术的进步使人们对淋巴管在健康和疾病中的作用有了新的认识。这包括免疫细胞与心脏淋巴管之间相互作用的基本方面。在白细胞和淋巴管内皮细胞的界面处，髓样细胞群体是炎症期间淋巴管生长因子的来源。淋巴管内皮细胞也分泌激活白细胞的信号，包括激活抗原呈递细胞。综上所述，一种将淋巴管系统视为心脏辅助免疫中心的观点正在形成。在此，我们讨论心肌中白细胞与淋巴管之间相互的细胞和分子相互作用，及其对健康和心脏炎症的影响。
