Strunk H, Börner N, Stuckmann G, Fröhlich E, Hadizadeh D
Radiologische Universitätsklinik Bonn.
Rofo. 2005 Oct;177(10):1394-404. doi: 10.1055/s-2005-858319.
Contrast enhanced sonography using phase-inversion harmonic mode is a promising technique to detect and characterize hepatic lesions. Aim of the following study was to evaluate whether this technique can characterize liver tumors.
During January and December 2004, 46 patients with a solitary liver lesion were examined. The age of the 21 women and 25 men ranged between 37 and 82 years. The tumor size was between 8 mm and 14.5 cm. First conventional B-mode sonography and color-coded sonography were performed, followed by intravenous injection of the contrast agent SonoVue and continuous sonographic examination over 5 minutes using "low MI real-time" phase-inversion mode. The examination was video taped. The enhancement was evaluated qualitatively.
Of the 21 malignant lesions, 20 could be correctly diagnosed as malignant. One of the malignant lesions was classified as benign. Of the 25 benign lesions, 21 could be classified correctly as benign, however, 4 lesions (2 hemangiomas, 1 adenoma, 1 teratoma) showed no enhancement in the portal and late phase and were incorrectly classified as malignant as well.
Using pulse-inversion harmonic US with SonoVue, liver lesions showing an isoechoic or hyperechoic enhancement can be classified as probably benign. Further work up is necessary in case of little or no enhancement on delayed phase imaging.
使用相位反转谐波模式的超声造影是一种检测和鉴别肝脏病变的有前景的技术。以下研究的目的是评估该技术是否能够鉴别肝脏肿瘤。
在2004年1月至12月期间，对46例有孤立性肝脏病变的患者进行了检查。21名女性和25名男性的年龄在37岁至82岁之间。肿瘤大小在8毫米至14.5厘米之间。首先进行常规B型超声检查和彩色编码超声检查，然后静脉注射造影剂声诺维，并使用“低机械指数实时”相位反转模式进行5分钟的连续超声检查。检查过程进行了录像。对增强情况进行定性评估。
21个恶性病变中，可以正确诊断出20个为恶性。其中1个恶性病变被分类为良性。25个良性病变中，21个可以正确分类为良性，然而，4个病变（2个血管瘤、1个腺瘤、1个畸胎瘤）在门静脉期和延迟期无增强，也被错误地分类为恶性。
使用声诺维的脉冲反转谐波超声检查时，表现为等回声或高回声增强的肝脏病变可能为良性。延迟期成像增强很少或无增强时，需要进一步检查。
