关于第二代全氟化碳乳剂。

On the perfluorocarbon emulsions of second generation.

作者信息

Meinert H, Fackler R, Knoblich A, Mader J, Reuter P, Röhlke W

机构信息

Universität Ulm, Abt. Anorganische Chemie, Federal Republic of Germany.

出版信息

Biomater Artif Cells Immobilization Biotechnol. 1992;20(1):95-113. doi: 10.3109/10731199209117860.

DOI:10.3109/10731199209117860

PMID:1617088

Abstract

For formulation of perfluorocarbon-emulsions (PFC-emulsions) of second generation new perfluorocarbons (F-dimorpholines, F-dipiperidines and F-cyclohexylmorpholine) were synthesized, acting both as oxygen carriers and as interfacial active compounds (IFACs). The stabilizing effect of these IFACs is interpreted and a new theory is introduced. Also new classes of fluorosurfactants were synthesized and tested for biocompatibility. In PFC mixtures compounds of the type RFRH (RF = CmF2m + 1, RH = CnH2n + 1) are acting as IFACs but also as anchor-groups for lipophilic surfactants.

摘要

为了制备第二代新型全氟碳（F - 二吗啉、F - 二哌啶和F - 环己基吗啉）的全氟碳乳液（PFC乳液），合成了兼具氧载体和界面活性化合物（IFACs）功能的物质。对这些IFACs的稳定作用进行了解释，并引入了一种新理论。还合成了新型氟表面活性剂并测试了其生物相容性。在PFC混合物中，RFRH型化合物（RF = CmF2m + 1，RH = CnH2n + 1）既作为IFACs，又作为亲脂性表面活性剂的锚定基团。