Draffehn J, Reichelt H
Institut für Klinische Chemie und Hämatologie, Militärmedizinischen Akademie Bad Saarow.
Pharmazie. 1991 Nov;46(11):800-2.
Oxygen uptake and desoxygenation in blood take place in the capillary system of the organism so that flow characteristics of blood substitutes should be adapted to that of microcirculation. Therefore, appropriate viscosity of blood substitutes is required. In addition to this, studies on the viscosity of blood substitutes made on the basis of perfluorocarbons are also of interest for considering the deemulsificability during circulation. Viscosity measurements carried out on highly polymerized dextran solutions determining the colloid osmotic pressure in blood substitutes, perfluorocarbon emulsions as oxygen carriers, blood as well as mixtures of these components showed that the rheological behaviour of blood substitutes examined did not lead to organic disorders.
机体血液中的氧摄取和脱氧过程在毛细血管系统中发生，因此血液代用品的流动特性应与微循环的流动特性相适应。所以，需要血液代用品具有适当的粘度。除此之外，基于全氟碳化合物的血液代用品的粘度研究对于考虑循环过程中的破乳性也很有意义。对高度聚合的右旋糖酐溶液进行的粘度测量，这些溶液用于测定血液代用品、作为氧载体的全氟碳化合物乳剂、血液以及这些成分的混合物中的胶体渗透压，结果表明所检测的血液代用品的流变行为不会导致器官功能紊乱。
