Reyes Dorantes Angel Andrés
Jefe del Departamento de Endoscopia, Hospital Central Militar México, D.F.
Rev Gastroenterol Mex. 2005 Jan-Mar;70(1):50-5.
For the primary prophilaxis of the variceal bleeding, non selective beta-blockers (propanolol, nadolol) are still the mainstay of treatment but endoscopic ligation are becoming more popular Thanks to modern control procedures the acute bleeding mortality has been reduced. Endoscopic ligation is the prefered method for esophageal varices and the cyanoacrylate injection is the better method for fundic varices. Pharmacological therapy with octreotide or terlipresine seems to be effective, specially if endoscopic treatment is not available. TIPS is a good salvage option in case of endoscopic or pharmacologic failure. Endoscopic ligation seems to be the prefered method for secondary prophylaxis, specially compared with sclerotherapy. Some drugs that reduce portal hypertension are a good alternative. It is still very necessary to define technique and criteria of endoscopic variceal eradication to reduce the great variability reported in published trials.
对于静脉曲张出血的一级预防,非选择性β受体阻滞剂(普萘洛尔、纳多洛尔)仍然是主要治疗方法,但内镜下套扎术正变得越来越受欢迎。由于现代控制程序,急性出血死亡率已有所降低。内镜下套扎术是治疗食管静脉曲张的首选方法,而氰基丙烯酸酯注射是治疗胃底静脉曲张的较好方法。使用奥曲肽或特利加压素进行药物治疗似乎有效,特别是在内镜治疗不可用时。经颈静脉肝内门体分流术(TIPS)在内镜或药物治疗失败的情况下是一种很好的挽救选择。内镜下套扎术似乎是二级预防的首选方法,特别是与硬化疗法相比。一些降低门静脉高压的药物是很好的替代方法。仍然非常有必要确定内镜下静脉曲张根除的技术和标准,以减少已发表试验中报道的巨大变异性。