Bátovský M
Gastroenterologická klinika Lekárskej fakulty Slovenskej zdravotníckej univerzity a UN Bratislava, Slovenská republika.
Vnitr Lek. 2011 Dec;57(12):989-92.
For the primary prophylaxis of variceal bleeding endoscopic band ligation has been shown to be as effective as non-selective beta-blockers (carvedilol), but variceal injection sclerotherapy is not generaly recommended in this setting because of higher rate of complications and lower effect in reducing either bleeding or mortality. Endoscopic management of acutely bleeding gastroesophageal varices includes injection sclerotherapy, rubber band ligation, and variceal obturation with tissue adhesives. Variceal injection sclerotherapy remains a quick, simple and cheap technique for the control of active bleeding from esophageal varices, but is associated with more rebleeding than variceal band ligation, which is now preferred also for lower rate of complications. Endoscopic sclerotherapy has increasingly been replaced by ligation also in secondary prophylaxis of variceal bleeding. The studies showed that band ligation can eradicate varices in fewer sessions, re-bleeding and complications were fewer in comparison with variceal injection sclerotherapy. Because of the reduced efficacy, severe complications, and the high mortality associated with using conventional sclerosants in acute bleeding gastric varices, the technique of injecting tissue adhesives has been studied, described and used despite numerous complications. Endoscopic injection sclerotherapy of esophageal varices remains usable as an oldest method in arresting of this hemorrhage only in rare cases when the band ligation is not available.
对于静脉曲张出血的一级预防,内镜下套扎术已被证明与非选择性β受体阻滞剂(卡维地洛)效果相当,但在此情况下,一般不推荐静脉曲张注射硬化疗法,因为其并发症发生率较高,且在减少出血或死亡率方面效果较差。急性胃食管静脉曲张出血的内镜治疗包括注射硬化疗法、橡皮圈套扎术以及用组织粘合剂闭塞静脉曲张。静脉曲张注射硬化疗法仍然是控制食管静脉曲张活动性出血的一种快速、简单且廉价的技术,但与静脉曲张套扎术相比,其再出血发生率更高,而静脉曲张套扎术目前因其并发症发生率较低而更受青睐。在内镜下静脉曲张出血的二级预防中,内镜硬化疗法也越来越多地被套扎术所取代。研究表明,套扎术能在更少的疗程内消除静脉曲张,与静脉曲张注射硬化疗法相比,再出血和并发症更少。由于使用传统硬化剂治疗急性出血性胃静脉曲张疗效降低、严重并发症及高死亡率,尽管存在诸多并发症,注射组织粘合剂的技术仍得到了研究、描述和应用。仅在极少数无法进行套扎术的情况下,食管静脉曲张内镜注射硬化疗法作为一种最古老的止血方法仍可使用。