Lack Leon, Wright Helen, Kemp Kristyn, Gibbon Samantha
School of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia 5001.
Sleep. 2005 May;28(5):616-23. doi: 10.1093/sleep/28.5.616.
To assess the effectiveness of brief bright-light therapy for the treatment of early-morning awakening insomnia.
Twenty-four healthy adults with early-morning awakening insomnia were assigned to either the bright-light condition (2,500-lux white light) or the control (dim red light) condition.
The circadian phase of rectal temperature and urinary melatonin rhythms were assessed with 26-hour constant routines before and after 2 evenings of light therapy. Sleep and daytime functioning were monitored using sleep diaries, activity monitors, and mood scales before light therapy and for 4 weeks during the follow-up period. While there were no significant circadian phase changes in the dim-light control group, the bright-light group had significant 2-hour phase delays of circadian temperature and melatonin rhythm. Compared to pretreatment measures, over the 4-week follow-up period, the bright-light group had a greater reduction of time awake after sleep onset, showed a trend toward waking later, and had a greater increase of total sleep time. Participants in the bright-light condition also tended to report greater reductions of negative daytime symptoms, including significantly fewer days of feeling depressed at the 4-week follow-up, as compared with the control group.
Two evenings of bright-light exposure phase delayed the circadian rhythms of early-morning awakening insomniacs. It also improved diary and actigraphy sleep measures and improved some indexes of daytime functioning for up to 1 month after light exposure. The study suggests that a brief course of evening bright-light therapy can be an effective treatment for early-morning awakening insomniacs who have relatively phase advanced circadian rhythms.
评估短程强光疗法治疗早醒失眠的有效性。
24名患有早醒失眠的健康成年人被分配到强光组(2500勒克斯白光)或对照组(昏暗红光)。
在两个晚上的光疗前后,通过26小时持续程序评估直肠温度和尿褪黑素节律的昼夜节律相位。在光疗前以及随访期间的4周内,使用睡眠日记、活动监测器和情绪量表监测睡眠和日间功能。暗光对照组的昼夜节律相位没有显著变化,而强光组的昼夜体温和褪黑素节律有显著的2小时相位延迟。与治疗前的测量结果相比,在4周的随访期内,强光组入睡后清醒时间的减少幅度更大,有晚起的趋势,总睡眠时间增加幅度更大。与对照组相比,强光组的参与者也倾向于报告白天负面症状的减少幅度更大,包括在4周随访时感到抑郁的天数显著减少。
两个晚上的强光照射使早醒失眠者的昼夜节律出现相位延迟。它还改善了日记和活动记录仪记录的睡眠指标,并在光照后长达1个月的时间里改善了一些日间功能指标。该研究表明,对于昼夜节律相对提前的早醒失眠者,短疗程的夜间强光疗法可能是一种有效的治疗方法。