Wang Yi, Zhao Xianchao, Ren Jiafeng, Xue Shengwen, Liu Yuhang, Zhang Liping, Fan Mengmeng, Su Changjun, Cheng Jin-Xiang
Sleep Medicine Center, Department of Neurology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710038, China.
Sleep Breath. 2024 Dec 29;29(1):66. doi: 10.1007/s11325-024-03204-z.
Light is a crucial factor influencing sleep arousal patterns. This meta-analysis investigates the efficacy of light therapy (LT) for insomnia treatment.
Five electronic databases were independently searched by two reviewers until August 2024. The literature screening focused specifically on populations with insomnia complaints treated by LT. Weighted Mean Difference (WMD) and 95% Confidence Interval (CI) were used as statistical tools, while the Cochrane Risk of Bias tool version 2 (RoB 2) was employed to assess the quality of evidence. A total of 10 randomized controlled trials (RCTs) were analyzed.
The results demonstrated that LT showed statistically significant improvements in subjective sleep quality, as evidenced by a reduction in Pittsburgh sleep quality scale (PSQI) scores by -2.89 (95% CI = -4.80 to -0.97) and Insomnia severity index (ISI) scores by -2.16 (95% CI = -4.23 to -0.08) post-intervention. Additionally, actigraphy revealed a statistically significant increase in total sleep time (TST) by 16.78 min (95% CI = 0.67 to 32.89) and a decrease in wake after sleep onset (WASO) by -12.91 min (95% CI = -25.62 to -0.20) by LT.
The preliminary results of the study suggest that LT has some efficacy in improving sleep quality in insomnia. However, it needs to be validated in future clinical trials with larger samples.
光线是影响睡眠觉醒模式的关键因素。本荟萃分析旨在研究光疗法（LT）治疗失眠的疗效。
两名评审员独立检索了五个电子数据库，直至2024年8月。文献筛选特别关注接受LT治疗的失眠患者群体。加权平均差（WMD）和95%置信区间（CI）用作统计工具，同时使用Cochrane偏倚风险工具第2版（RoB 2）评估证据质量。共分析了10项随机对照试验（RCT）。
结果表明，LT在主观睡眠质量方面有统计学显著改善，干预后匹兹堡睡眠质量指数（PSQI）得分降低-2.89（95%CI = -4.80至-0.97），失眠严重程度指数（ISI）得分降低-2.16（95%CI = -4.23至-0.08）。此外，活动记录仪显示，LT使总睡眠时间（TST）显著增加16.78分钟（95%CI = 0.67至32.89），睡眠后觉醒时间（WASO）减少-12.91分钟（95%CI = -25.62至-0.20）。
该研究的初步结果表明，LT在改善失眠患者的睡眠质量方面有一定疗效。然而，需要在未来更大样本的临床试验中进行验证。
