Makáry A, Kolthay E, Pataki M, Petö J, Kovács G, Lusztig G
County Hospital of Kecskemét, Department of Pathology, Hungary.
Exp Toxicol Pathol. 1992 Apr;44(2):105-7. doi: 10.1016/S0940-2993(11)80197-1.
It has been supposed that prostacyclin (PGI2) and its analogues have important antiatherogenic effects. The aim of this work was to test the effect of PGI2 and 7-oxo-PGI2- (a stable analogue of PGI2) (6) treatment on the acyl CoA: cholesterol-acyltransferase (ACAT) activity in the aortic wall of rabbits. The rabbits had been previously fed with cholesterol and treated with PGI2 and 7-oxo-PGI2 intravenously. Cholesterol feeding increased ACAT activity compared to the control group which was not fed with cholesterol: 16.84 nmol/mg prot./h and 10.03 nmol/mg prot./h, respectively. PGI2 treatment of the cholesterol fed group did not cause a significant decrease, while 7-oxo-PGI2 treatment significantly decreased aortic ACAT activity compared to the cholesterol-fed control group; 14.31 nmol/mg prot./h; 11.53 nmol/mg prot./h and 16.84 nmol/mg prot./h, respectively. The decrease found in the ACAT activity after PGI2 and 7-oxo-PGI2 treatment are new data for the protective effect of these agents against atherosclerosis.
人们认为前列环素（PGI2）及其类似物具有重要的抗动脉粥样硬化作用。本研究的目的是测试PGI2和7-氧代-PGI2-（PGI2的一种稳定类似物）（6）处理对兔主动脉壁中酰基辅酶A：胆固醇酰基转移酶（ACAT）活性的影响。这些兔子先前已喂食胆固醇，并通过静脉注射给予PGI2和7-氧代-PGI2。与未喂食胆固醇的对照组相比，喂食胆固醇增加了ACAT活性：分别为16.84 nmol/mg蛋白/小时和10.03 nmol/mg蛋白/小时。胆固醇喂食组的PGI2处理未导致显著降低，而与胆固醇喂食对照组相比，7-氧代-PGI2处理显著降低了主动脉ACAT活性；分别为14.31 nmol/mg蛋白/小时、11.53 nmol/mg蛋白/小时和16.84 nmol/mg蛋白/小时。PGI2和7-氧代-PGI2处理后ACAT活性的降低是这些药物对动脉粥样硬化保护作用的新数据。
