他克莫司治疗两名难治性间质性肺病合并多肌炎/皮肌炎患者取得良好疗效。
Favorable outcomes with tacrolimus in two patients with refractory interstitial lung disease associated with polymyositis/dermatomyositis.
作者信息
Ochi S, Nanki T, Takada K, Suzuki F, Komano Y, Kubota T, Miyasaka N
机构信息
Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
Clin Exp Rheumatol. 2005 Sep-Oct;23(5):707-10.
Two cases of progressive interstitial lung disease associated with polymyositis/dermatomyositis are presented. Both patients were refractory to conventional therapy with high-dose corticosteroids, cyclosporine, and intermittent pulse cyclophosphamide, and thus a therapeutic trial of tacrolimus was instituted. Tacrolimus was markedly effective in achieving subjective, laboratory and radiographic improvement in both patients.
本文报告两例与多发性肌炎/皮肌炎相关的进行性间质性肺病。两名患者对大剂量皮质类固醇、环孢素和间歇性脉冲环磷酰胺的传统治疗均无效，因此开展了他克莫司的治疗试验。他克莫司在使两名患者的主观症状、实验室检查和影像学表现均得到改善方面显著有效。
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