肥大海兔已鉴定的光反应性踏板神经元中经典条件反射的细胞关联

Cellular correlates of classical conditioning in identified light responsive pedal neurons of Hermissenda crassicornis.

作者信息

Hodgson T M, Crow T

机构信息

Department of Neurobiology and Anatomy, University of Texas, School of Medicine, Houston 77225.

出版信息

Brain Res. 1992 Jan 20;570(1-2):267-71. doi: 10.1016/0006-8993(92)90590-6.

DOI:10.1016/0006-8993(92)90590-6

PMID:1617416

Abstract

Cellular correlates of classical conditioning were examined in two recently identified light responsive pedal neurons. The correlates of conditioning consisted of significant decreases in the pedal cells' responses to light (conditioned stimulus) recorded from conditioned animals compared to random controls. Pedal cell P7, which exhibits an inhibitory response to light in naive animals, showed significantly less inhibition during a 5 min light step in conditioned animals as compared to random controls. Pedal neuron P9, which exhibits an excitatory response to light in naive animals, showed significantly less excitation during a 10 s light step in conditioned animals as compared to random controls. The changes in the response to light recorded from pedal neurons P7 and P9 in conditioned animals were not accompanied by any significant changes in membrane potential, action potential amplitude or dark-adapted spike frequency.

摘要

在最近发现的两个光反应性踏板神经元中，研究了经典条件反射的细胞关联。条件反射的关联表现为，与随机对照相比，从条件化动物记录到的踏板细胞对光（条件刺激）的反应显著降低。在未接触过条件刺激的动物中，踏板细胞P7对光表现出抑制反应，与随机对照相比，在条件化动物中，P7在5分钟的光照阶段表现出明显较少的抑制作用。在未接触过条件刺激的动物中，踏板神经元P9对光表现出兴奋反应，与随机对照相比，在条件化动物中，P9在10秒的光照阶段表现出明显较少的兴奋作用。在条件化动物中，踏板神经元P7和P9记录到的对光反应的变化，并未伴随着膜电位、动作电位幅度或暗适应尖峰频率的任何显著变化。