Martin William F, Armstrong Lawrence E, Rodriguez Nancy R
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
Department of Kinesiology, University of Connecticut, Storrs, CT, USA.
Nutr Metab (Lond). 2005 Sep 20;2:25. doi: 10.1186/1743-7075-2-25.
Recent trends in weight loss diets have led to a substantial increase in protein intake by individuals. As a result, the safety of habitually consuming dietary protein in excess of recommended intakes has been questioned. In particular, there is concern that high protein intake may promote renal damage by chronically increasing glomerular pressure and hyperfiltration. There is, however, a serious question as to whether there is significant evidence to support this relationship in healthy individuals. In fact, some studies suggest that hyperfiltration, the purported mechanism for renal damage, is a normal adaptative mechanism that occurs in response to several physiological conditions. This paper reviews the available evidence that increased dietary protein intake is a health concern in terms of the potential to initiate or promote renal disease. While protein restriction may be appropriate for treatment of existing kidney disease, we find no significant evidence for a detrimental effect of high protein intakes on kidney function in healthy persons after centuries of a high protein Western diet.
近期减肥饮食的趋势导致个人蛋白质摄入量大幅增加。因此，习惯性摄入超过推荐量的膳食蛋白质的安全性受到了质疑。特别是，人们担心高蛋白摄入可能通过长期增加肾小球压力和超滤作用而促进肾脏损害。然而，对于健康个体中是否有重要证据支持这种关系存在严重疑问。事实上，一些研究表明，超滤作用，即所谓的肾脏损害机制，是一种正常的适应性机制，会在多种生理状况下出现。本文综述了现有证据，即就引发或促进肾脏疾病的可能性而言，增加膳食蛋白质摄入量是否会对健康构成威胁。虽然蛋白质限制可能适用于现有肾脏疾病的治疗，但在西方高蛋白饮食数百年之后，我们并未发现有重要证据表明高蛋白摄入对健康人的肾功能有不利影响。
