Palmer Keith T, Calnan Michael, Wainwright David, Poole Jason, O'Neill Claire, Winterbottom Anna, Watkins Chris, Coggon David
MRC Environmental Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.
Occup Med (Lond). 2005 Dec;55(8):612-7. doi: 10.1093/occmed/kqi142. Epub 2005 Sep 20.
Somatization (a tendency to report distress from somatic symptoms) is a little studied, but potentially important, confounder and effect modifier in occupational studies of musculoskeletal disease.
To assess the role of somatization as a risk factor for disabling regional pain.
A questionnaire was mailed to 4998 subjects of working age. Questions were asked about chronic and disabling pain in the past 12 months affecting the arm, low back, knee or combinations of these sites. Distress from physical symptoms was assessed using elements of the Brief Symptom Inventory and mental well-being was assessed using the short-form 36 (SF-36). Associations were examined by modified Cox regression and expressed as hazard ratios (HRs) with 95% confidence intervals (CI).
Among 2632 responders, 24% reported chronic pain and 25% disabling pain at one or several sites. Risk of chronic or disabling pain increased strongly according to the number of somatic symptoms reported as bothersome. For example, the HR for chronic upper limb pain in those distressed by > or =2 somatic symptoms in the past 7 days versus none was 3.9 (95% CI 2.9-5.3), and that of disabling upper limb pain was 5.8 (95% CI 4.1-8.3). Similar patterns were found for the low back and knee, and there was a gradient of increasing risk according to the number of sites with disabling pain. In comparison, associations with SF-36 mental well-being score were weaker.
Somatizing tendency should be evaluated as a possible confounder or effect modifier in studies of occupational risk factors for musculoskeletal pain.
躯体化(报告躯体症状所致痛苦的倾向)在肌肉骨骼疾病的职业研究中是一个研究较少但可能很重要的混杂因素和效应修饰因素。
评估躯体化作为导致残疾性局部疼痛的危险因素的作用。
向4998名工作年龄的受试者邮寄了一份问卷。询问了过去12个月中影响手臂、下背部、膝盖或这些部位组合的慢性和致残性疼痛情况。使用简明症状量表的项目评估躯体症状所致痛苦,使用简短健康调查问卷(SF-36)评估心理健康状况。通过修正的Cox回归分析关联性,并以95%置信区间(CI)的风险比(HRs)表示。
在2632名应答者中,24%报告了一个或多个部位的慢性疼痛,25%报告了致残性疼痛。根据报告为令人烦恼的躯体症状数量,慢性或致残性疼痛的风险显著增加。例如,在过去7天内有≥2种躯体症状困扰的人群中,慢性上肢疼痛的HR为3.9(95%CI 2.9 - 5.3),致残性上肢疼痛的HR为5.8(95%CI 4.1 - 8.3)。下背部和膝盖也发现了类似模式,并且根据致残性疼痛部位的数量存在风险增加的梯度。相比之下,与SF-36心理健康评分的关联性较弱。
在肌肉骨骼疼痛职业危险因素的研究中,应将躯体化倾向评估为可能的混杂因素或效应修饰因素。